Many supplements that decrease systemic inflammation also have direct and indirect effect on NAD+ levels.
Supplements to Restore NAD+
- NAD+ and NAD+ precursor supplements
- Increase endogenous NAD+ production
- Decrease NAD+ consumption in the body
NAD+ and NAD+ Precursors
Increase Endongenous NAD+ Production
Our bodies constantly recycle NAD+ in what is called the salvage pathway. The bottleneck in this process is NAMPT. Activating AMPK increases NAMPT to increase NAD+ through the salvage pathway.
Decrease Inflammation and Increase NAD+
The chart below shows the supplements we offer for health and longevity in addition to NAD+ precursors
All can help lower systemic inflammation.
Inflammation Increases with Age
In this video, Dr. Michael Lustgarten does a great job of showing how inflammation (measured by HS-CRP) increases with age.
Inflammation Increases CD38
In ageing, declining NAD+ levels are associated with increased accumulation of proinflammatory M1-like resident macrophages in the liver and fat, which are characterized by increased expression of CD38 (r).
This research review by Dr. Sinclair found increased CD38 responsible for the lower NAD+ levels as we age.
the major culprit is an NADase called CD38 whose levels rise during aging
Inflammation Drives Mortality
This study found inflammation is a better predictor of mortality than telomere length.
We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans (r).
Decreased Inflammation Helps NAD+ Levels
Results from hundreds of tests for Intracellular NAD+ levels tell us that those with high inflammation levels (measured by HS-CRP) have less success raising NAD+ levels.
Lowering inflammation can help restore NAD+ levels on their own, and also allow NAD+ precursors to work even better.
By lowering inflammation along with use of effective NAD+ precursors, we have seen increases of 300% in some subjects vs 50% with NAD+ precursors alone.