A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth of smooth muscle cells and improved blood vessel healing in rats with narrowed arteries.
Category Archives: NAD+
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within the body are distinct. Understanding these individual pathways is crucial, as they may have significant effects on outcomes beyond just the NAD+ level itself.
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast onset of pharmacological action."
“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy and cardiac function, inhibits myocardial fibrosis, and reduces the myocardial infarction rate.”
A recent literature review explored the impact of extracellular NAD+ on the inflammatory response.
“NMN had the highest concentrations in breast milk among the NAD-related substances. We demonstrated, for the first time, a positive relationship between NMN concentrations in breast milk and the neurodevelopmental outcome of a child.”
This study evaluated the effects of NAD+ injections in patients with heart failure.
Sepsis-associated disruption of the NRK1/2 pathway for NAD+ synthesis emphasized the critical role of NMN transport through the Slc12a8 transporter.
NAD+ deficiency is not just a concern of aging; it also plays a significant role in the development of various chronic diseases that are on the rise among younger generations.
This study showed that NR (1 g/day) for 10 weeks is safe in adults with MCI and effectively increased blood levels of NAD+.
New research on NAD+ metabolism, NMN supplementation, and mitochondrial NAD+ levels was presented at the esteemed longevity conference, the Aging Research and Drug Discovery (ARDD) Meeting.