Category Archives: NR

NR Regulates the Cardiac Internal Clock of Aged Mice

Circadian rhythm is your body’s internal clock that permits anticipation of daily patterns, regulating when it’s time to sleep, wake up, eat, and digest. This study evaluated the effects of NR supplementation on age-related changes in the heart’s circadian rhythm.

Study Shows NR Protects the Intestine From Damage Caused by Excessive Alcohol Intake

NR Preserved Intestinal Lining Integrity During Excessive Alcohol Intake

“In particular, the intestine, as the main organ of ethanol absorption, is susceptible to serious injury from excess drinking.”

When mice were given alcohol without NR supplementation, it led to higher levels of intestinal contents entering their bloodstream, suggesting damage to the intestinal lining.

Study Shows NR Injections Increase Muscle NAD+ in Mice, Oral Supplementation Does Not

NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.

A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).

NAD Precursors Cycle Between Host Tissues and the Gut Microbiome

Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.

Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver

Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR