This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
Category Archives: NMN
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within the body are distinct. Understanding these individual pathways is crucial, as they may have significant effects on outcomes beyond just the NAD+ level itself.
“We showed that NMN consistently extended the healthy and median lifespan of Zmpste24-/- and improved the Zmpste24-/- ageing phenotype."
This article delves into the scientific evidence concerning NMN, SARM1 activation, and their impact on axonal health.
“We demonstrated that NMN could ameliorate psoriasis-like symptoms and inflammation in an IMQ-stimulated mouse model and improve therapeutic prognoses by activating the SIRT1 pathway.”
This study evaluated the effects of intraperitoneal (i.p.) injections of NMN on tumor-induced cellular aging, inflammation, mitochondrial function, and survival in mice.
“NMN had the highest concentrations in breast milk among the NAD-related substances. We demonstrated, for the first time, a positive relationship between NMN concentrations in breast milk and the neurodevelopmental outcome of a child.”
“We have demonstrated that this methodology can accurately quantitate NMN levels in mouse plasma and confirmed quick, direct NMN uptake into blood circulation and cells.”
“NMN exerts neuroprotective effects after SCI by the regulation of certain genes acting on signaling pathways related to neurological diseases.”
Sepsis-associated disruption of the NRK1/2 pathway for NAD+ synthesis emphasized the critical role of NMN transport through the Slc12a8 transporter.
The study developed a novel microfluidic approach to co-encapsulate NMN and an anticancer drug, honokiol (HNK), in liposomes and established a new HPLC method for NMN encapsulation quantification.
New research on NAD+ metabolism, NMN supplementation, and mitochondrial NAD+ levels was presented at the esteemed longevity conference, the Aging Research and Drug Discovery (ARDD) Meeting.