This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
Category Archives: Neurological
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast onset of pharmacological action."
This article delves into the scientific evidence concerning NMN, SARM1 activation, and their impact on axonal health.
“NMN had the highest concentrations in breast milk among the NAD-related substances. We demonstrated, for the first time, a positive relationship between NMN concentrations in breast milk and the neurodevelopmental outcome of a child.”
“NMN exerts neuroprotective effects after SCI by the regulation of certain genes acting on signaling pathways related to neurological diseases.”
This study showed that NR (1 g/day) for 10 weeks is safe in adults with MCI and effectively increased blood levels of NAD+.
Many diseases and biological stressors disrupt NAD+ metabolism and are associated with low levels of NAD+, such as obesity, infection, alcohol consumption, and high blood pressure.
Berberine is a bioactive compound found in many plants, including goldenseal, Oregon grape, and barberry. It has been recognized for its health benefits for centuries, with its earliest known therapeutic use dating back to A.D. 200. Today, Berberine continues to be an exciting focus of health and wellness research, with many studies investigating its potential for maintaining metabolic health.
Palmitoylethanolamide (PEA) is a natural compound that your body produces in response to various forms of cellular damage. Its primary role is to promote homeostasis, which is the body’s ability to maintain a stable and balanced internal environment for optimal functioning and overall wellness.
“But until now, it was unknown whether NR reached targeted organs like the brain to have a real therapeutic effect,” according to Christopher Martens, one of the key researchers in this study, and the director of the Delaware Center for Cognitive Aging Research.
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