Category Archives: Cardiovascular

NAD+ Injections Guard Against Heart Failure in Rats and Beagles

“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy and cardiac function, inhibits myocardial fibrosis, and reduces the myocardial infarction rate.”

Study Shows Spermidine Enhances Blood Flow Recovery and Promotes Blood Vessel Generation in Aged Mice

A recent study evaluated the therapeutic efficacy of Spermidine for blood flow recovery and blood vessel growth after artificially blocked blood flow in mice.

“Spermidine is a naturally occurring polyamine that has shown substantial evidence of anti-aging properties”

Study Shows NMN Reduces Arterial Stiffness & Blood Pressure

“Several human clinical trials indicate that NR and NAM supplementation decrease the risk factors of CVDs, such as hypertension, arterial stiffness, and elevated level of low-density lipoprotein cholesterol 13,14.”

Although NMN has been proven to improve vascular dysfunction in mice, it has not been thoroughly evaluated in humans.

New Human Trial Shows NMN Reduced Blood Vessel Stiffness and Significantly Decreased Diastolic Blood Pressure

A new human trial using 36 healthy middle-aged participants was recently published showing positive efficacy for NMN.  In this 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial, it was shown that just 125mg of NMN twice per day reduced blood vessel stiffness and significantly decreased diastolic blood pressure in participants with elevated glucose levels. (1) NAD+ […]

NMN and Resveratrol Work Synergistically to boost NAD+ in Heart and Skeletal Muscle

A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+ levels in both heart and skeletal muscle tissues in mice. Combination treatments shown to boost efficacy It is becoming more common to treat age-related diseases with anti-aging cocktails, including NAD+ or NMN to boost efficacy.  NMN has been shown […]

Heart Disease Related to Accumulation of DNA Damage and Oxidative Stress

As we age, the risk for clogged arteries, brittle blood vessels, and heart failure increase. A recent study looking at the DNA in numerous individual heart cells tells the story of why this occurs Buildup of Damaged DNA and Faltering Ability to Repair Damage In a ground-breaking study spanning 0 to 82 year olds, they […]

Trimethylglycine (TMG) for Restoring Methylation, Homocysteine Levels, Heart Health, and Liver Function

TMG – the Insurance Policy Against Loss of Methyl Groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take glycine, specifically trimethylglycine is to counter what I think may be going on with an NAD+ booster”… […]

Study Shows NMN Supplementation or CD38 Inhibition Restores Cardiovascular Function in Mice

CD38 Deficiency Alleviates Ang II-Induced Vascular Remodeling By Inhibiting Small Extracellular Vesicle-Mediated Vascular Smooth Muscle Cell Senescence In Mice (Lu Gan, June 2021) In this study, researchers investigated the impact of NMN supplementation and CD38 inhibition on the cardiovascular function in mice. Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It […]