This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
Category Archives: Longevity Supplements
“We showed that NMN consistently extended the healthy and median lifespan of Zmpste24-/- and improved the Zmpste24-/- ageing phenotype."
The possible advantages of using Niacin for heart health have been recognized for decades. Research dating back to 1955 revealed that high doses of Niacin could notably decrease cholesterol levels in humans.
This study found that the continued administration of Green Tea Catechin (EGCG) improves the lifespan, cellular health, and cell waste clearance in aging mice.
Sepsis-associated disruption of the NRK1/2 pathway for NAD+ synthesis emphasized the critical role of NMN transport through the Slc12a8 transporter.
A recent systematic review evaluated ten studies with NAD+ precursors for efficacy and safety.
“Upon oral administration, NMN–HAP nanoparticles demonstrated prolonged circulation time and enhanced bioavailability compared with free NMN, leading to elevated plasma levels of both NAD+ and its precursor, NR.”
Hesperidin is a flavonoid, a type of plant compound that has been shown to have a wide range of health benefits. It is found primarily in citrus fruits, such as oranges, lemons, grapefruit, and limes. Hesperidin exhibits anti-inflammatory and antioxidant activity, protecting cells from two key contributors to the onset of age-related and chronic diseases: inflammation and oxidative stress.
Modern research supports the traditional uses of Ashwaganda, showing it may help reduce stress, anxiety, fatigue, improve cognitive function, boost the immune system, and help manage blood sugar levels.
“These results suggest that NMN treatment functionally ameliorated or prevented exacerbation of heart failure in p32 cardiomyocyte–specific knockout mice, thereby prolonging their lifespan.”
This study showed that Quercetin protected rats with osteoarthritis against bone and cartilage damage by reducing inflammation and modulating levels of proteins associated with cartilage health.
“Overall, the present study may shed new light on novel strategies in which NAD+ boosting therapy, including NMN supplement and CD38 inhibition, may turn out to be a promising therapeutic measure to treat patients with hypertension.”