NAD+ for Metabolism and Brain, NMN for the body?

Do NMN and NAD⁺ have different effects on the body?

Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their lifespan.

Although they have similar effect in some organs, there may be differences in the effect they have in other tissues throughout the body.

NAD⁺ in IV or IP injections

Research has been successful using NAD⁺ injections in mice.

In humans, clinics that provide NAD⁺ by IV are exploding in popularity, even though they charge over $1,000 a day and require the patient to be hooked up to a drip IV for 8 hours.

NMN and NR poor bioavailability in capsules

NMN and NR capsules are only partially digested in the stomach, but are almost totally metabolized in the liver and excreted as NAM (Liu, 2018).

Sublingual delivery solves the bioavailability problem

Molecules like NMN, NR and NAD⁺ that have low molecular weight and are hydrophilic can be absorbed through the capillaries under the tongue directly into the bloodstream. This is called Sublingual (under the tongue) delivery.

Sublingual delivery can bypass the stomach and liver.

This may solve the bioavailability problem of capsules that get digested in the stomach, so NAD⁺ can be used instead of NAD⁺ precursors. It also may  improve the effectiveness of NMN.

Why is there no sublingual NR?

Nicotinamide Riboside is not stable by itself, so Chromadex adds Chloride to make it stable.

ALL NR sold is actually Nicotinamide Riboside with CHLORIDE.

Unfortunately, the taste is not acceptable for sublingual use.

So NR is only available in capsule form, which much pass through the stomach and liver where it is metabolized to the less effective Nicotinamide (Liu, 2018) .