Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]
Category Archives: Research
This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups were removed from the mothers and fed normal chow. These improvements in health and behavior persisted for […]
Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered […]
Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, increases NAD+ levels, reduces hunger and weight gain, and increases energy expenditure and fat burning in mice. This study shows that increased NAD+ […]
Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which restored NAD+ levels in the hypothalamus to normal levels. 1 The hypothalamus is the master regulator of metabolism. Decreased levels […]