This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. https://assets.researchsquare.com/files/rs-87047/v1_stamped.pdf Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, […]
This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+ Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside Like prior studies (1), they found that this transport method did not […]
Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on a vast range of age-related disorders through improving the levels of ATP. Declining ATP as we age […]
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potentialtherapeutic strategy to mitigate aging-related disorders in humans.
This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]
Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]