Category Archives: Metabolic Health

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potentialtherapeutic strategy to mitigate aging-related disorders in humans.

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, increases NAD+ levels, reduces hunger and weight gain, and increases energy expenditure and fat burning in mice. This study shows that increased NAD+ […]

Exogenous NAD+ Increases Metabolism

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels in the hypothalamus to normal levels. 1 The hypothalamus is the master regulator of metabolism.  Decreased levels […]

NAD+ for Metabolism and Brain, NMN for the body?

Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their lifespan.

Although they have similar effect in some organs, there may be differences in the effect they have in other tissues throughout the body.