New research on NAD+ metabolism, NMN supplementation, and mitochondrial NAD+ levels was presented at the esteemed longevity conference, the Aging Research and Drug Discovery (ARDD) Meeting.
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“Results from the humanized mouse study demonstrated that NMN treatment could improve the therapeutic effect of cART in vivo on reconstituting CD4+ T cells and improving CD4/CD8 ratio significantly over time.”
“Upon oral administration, NMN–HAP nanoparticles demonstrated prolonged circulation time and enhanced bioavailability compared with free NMN, leading to elevated plasma levels of both NAD+ and its precursor, NR.”
“These results suggest that NMN treatment functionally ameliorated or prevented exacerbation of heart failure in p32 cardiomyocyte–specific knockout mice, thereby prolonging their lifespan.”
“Overall, the present study may shed new light on novel strategies in which NAD+ boosting therapy, including NMN supplement and CD38 inhibition, may turn out to be a promising therapeutic measure to treat patients with hypertension.”
Oral administration of NMN (500 mg/kg) effectively preserved NAD+ tissue and plasma levels during PM exposure and protected against pulmonary fibrosis in mice.