This study evaluated the safety and effects of high-dose (3,000 mg) Nicotinamide Riboside (NR) supplementation in patients with Parkinson’s Disease (PD).
Circadian rhythm is your body’s internal clock that permits anticipation of daily patterns, regulating when it’s time to sleep, wake up, eat, and digest. This study evaluated the effects of NR supplementation on age-related changes in the heart’s circadian rhythm.
NR Preserved Intestinal Lining Integrity During Excessive Alcohol Intake
“In particular, the intestine, as the main organ of ethanol absorption, is susceptible to serious injury from excess drinking.”
When mice were given alcohol without NR supplementation, it led to higher levels of intestinal contents entering their bloodstream, suggesting damage to the intestinal lining.
NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.
A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).