This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
Author Archives: Rebecca Crews
“Our results add trigonelline to the list of established dietary NAD+ boosters.”
A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth of smooth muscle cells and improved blood vessel healing in rats with narrowed arteries.
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within the body are distinct. Understanding these individual pathways is crucial, as they may have significant effects on outcomes beyond just the NAD+ level itself.
“We showed that NMN consistently extended the healthy and median lifespan of Zmpste24-/- and improved the Zmpste24-/- ageing phenotype."
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast onset of pharmacological action."
The possible advantages of using Niacin for heart health have been recognized for decades. Research dating back to 1955 revealed that high doses of Niacin could notably decrease cholesterol levels in humans.
This article delves into the scientific evidence concerning NMN, SARM1 activation, and their impact on axonal health.
“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy and cardiac function, inhibits myocardial fibrosis, and reduces the myocardial infarction rate.”
A recent literature review explored the impact of extracellular NAD+ on the inflammatory response.
“We demonstrated that NMN could ameliorate psoriasis-like symptoms and inflammation in an IMQ-stimulated mouse model and improve therapeutic prognoses by activating the SIRT1 pathway.”