New research on NAD+ metabolism, NMN supplementation, and mitochondrial NAD+ levels was presented at the esteemed longevity conference, the Aging Research and Drug Discovery (ARDD) Meeting.
Tag Archives: cd38
Two recent studies have found that inhibition of CD38 (with 78c or PCC1) increase NAD+ levels and result in significant increases in lifespan and healthspan in mice.
CD38 Increases as We Age and Drives Down NAD+ Levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that CD38 levels increase, and that NAD+ decreases as we age. A 2016 study found that the increased levels of CD38 are a primary driver of decreasing levels of NAD+ […]
CD38 Deficiency Alleviates Ang II-Induced Vascular Remodeling By Inhibiting Small Extracellular Vesicle-Mediated Vascular Smooth Muscle Cell Senescence In Mice (Lu Gan, June 2021) In this study, researchers investigated the impact of NMN supplementation and CD38 inhibition on the cardiovascular function in mice. Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It […]