"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast onset of pharmacological action."
Author Archives: Rebecca Crews
The possible advantages of using Niacin for heart health have been recognized for decades. Research dating back to 1955 revealed that high doses of Niacin could notably decrease cholesterol levels in humans.
This article delves into the scientific evidence concerning NMN, SARM1 activation, and their impact on axonal health.
“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy and cardiac function, inhibits myocardial fibrosis, and reduces the myocardial infarction rate.”
A recent literature review explored the impact of extracellular NAD+ on the inflammatory response.
“We demonstrated that NMN could ameliorate psoriasis-like symptoms and inflammation in an IMQ-stimulated mouse model and improve therapeutic prognoses by activating the SIRT1 pathway.”
This study evaluated the effects of intraperitoneal (i.p.) injections of NMN on tumor-induced cellular aging, inflammation, mitochondrial function, and survival in mice.
“NMN had the highest concentrations in breast milk among the NAD-related substances. We demonstrated, for the first time, a positive relationship between NMN concentrations in breast milk and the neurodevelopmental outcome of a child.”
“We have demonstrated that this methodology can accurately quantitate NMN levels in mouse plasma and confirmed quick, direct NMN uptake into blood circulation and cells.”
This study evaluated the effects of NAD+ injections in patients with heart failure.
“NMN exerts neuroprotective effects after SCI by the regulation of certain genes acting on signaling pathways related to neurological diseases.”
This study found that injection of NMN protected mice from asthma-induced inflammation, mucus production, and lung barrier disruption.