“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway by which NAD+-boosting agent nicotinamide mononucleotide (NMN) regulates MSR in AD models.”
Category Archives: NMN
This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health in male and female mice. Effects of NMN on Lifespan and Healthspan in Aging Mice Mice were divided into two main groups based on sex and treatment: NMN group: Received NMN in drinking water (~550 mg/kg/day). Control group: Received regular […]
This research reviews the current evidence on NMN metabolism and compares the effects of different administration routes.
“Because of the high interindividual variability of the NADΔ after NMN supplementation, monitoring NAD concentration can provide valuable insights for tailoring personalized dosage regimens and optimizing NMN utilization.”
“These results indicate that NMN intake could increase blood NAD + levels, maintain walking speed, and improve sleep quality in older adults.”
A recent study investigated the effects of NMN and NR on ovary health and function in middle-aged rats. “This study reveals that NMN alone or NR alone can rebalance mitochondrial dynamics by decreasing excessive fission in middle-aged rat ovaries, thus alleviating mitochondrial stress and correcting aging-induced folliculogenesis abnormalities.” This graph shows the number of healthy […]
This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within the body are distinct. Understanding these individual pathways is crucial, as they may have significant effects on outcomes beyond just the NAD+ level itself.