Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell). In order to work collectively and maintain the homeostasis across multiple tissues, our cells have developed multiple different ways to receive, process, and transmit information between each other, including endocrine, […]
Category Archives: Research
Two recent studies have found that inhibition of CD38 (with 78c or PCC1) increase NAD+ levels and result in significant increases in lifespan and healthspan in mice.
Resveratrol is a polyphenol derived from plants with antioxidant properties that have been shown to enhance the activation of the body’s own self-repair proteins, called sirtuins. When sirtuins are activated, the effect is delayed aging, which has been demonstrated in a wide spectrum of experimental models, including mammals.
In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which restored NAD+ levels in the hypothalamus to normal levels. 1
The hypothalamus is the master regulator of metabolism. Decreased levels of NAD+ are found in hypothalamus with obesity, disease and the normal aging process.
TMG – the Insurance Policy Against Loss of Methyl Groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take glycine, specifically trimethylglycine is to counter what I think may be going on with an NAD+ booster”… […]
Mitochondria – More than Powerplants in Cells Mitochondria are the large organelles that exist in most human cells. They are the critical organelles that generate ATP through the respiratory chain and produce the intermediate metabolites that are essential to various cellular processes. During aging, the respiratory chain losses its efficacy and the membrane of the […]
NAD+ Precursors and Healthy Aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the substrate for enzymes such as the sirtuins. One of the hallmarks of aging is declining cellular NAD+ levels. Moreover, many studies carried out in different […]
Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Further, a pharmacological manipulation that mimics a state of limited nutrient availability, such as rapamycin, can extend longevity in mice (Harrison et al., 2009). In […]
This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. https://assets.researchsquare.com/files/rs-87047/v1_stamped.pdf Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, […]
This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+ Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside Like prior studies (1), they found that this transport method did not […]
Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on a vast range of age-related disorders through improving the levels of ATP. Declining ATP as we age […]