NMN & NAD+ PRECURSORS

NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct
NMN Improved Aging Parameters in Clinical Trial

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11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug
NMN Enhances Cellular Protection and Cognitive Function in Alzheimer’s Disease Mice

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20
Aug

LATEST ARTICLES

Aging & Longevity, Longevity Supplements, NAD+, NMN, NR

Why Too Much NMN or NR is Bad

Posted on by David Giacometti

If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated […]

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Aging & Longevity, Longevity Supplements, NAD+, NMN, Research

Reduced Nicotinamide Mononucleotide – A Tale of Four NAD+ Precursors

Posted on by David Giacometti

NAD+ Precursors and Healthy Aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the substrate for enzymes such as the sirtuins. One of the hallmarks of aging is declining cellular NAD+ levels.  Moreover, many studies carried out in different […]

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Aging & Longevity, Longevity Supplements, NAD+, Research

NAD+ and the Hallmarks of Aging Series – Part 5: Deregulated Nutrient Sensing

Posted on by David Giacometti

Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Further, a pharmacological manipulation that mimics a state of limited nutrient availability, such as rapamycin, can extend longevity in mice (Harrison et al., 2009). In […]

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Bone & Muscle, Cardiovascular, NAD+, NMN

Study Shows NMN Supplementation or CD38 Inhibition Restores Cardiovascular Function in Mice

Posted on by David Giacometti

CD38 Deficiency Alleviates Ang II-Induced Vascular Remodeling By Inhibiting Small Extracellular Vesicle-Mediated Vascular Smooth Muscle Cell Senescence In Mice (Lu Gan, June 2021) In this study, researchers investigated the impact of NMN supplementation and CD38 inhibition on the cardiovascular function in mice. Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It […]

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Aging & Longevity, Intestinal Health, Longevity Supplements, Research

Bacteria in Gastrointestional Tract Metabolize NMN and Impact NAD+ Metabolome

Posted on by David Giacometti

This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. https://assets.researchsquare.com/files/rs-87047/v1_stamped.pdf Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, […]

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Aging & Longevity, Longevity Supplements, NAD+, Research

CD73 utilization shows importance of NMN to restore NAD+

Posted on by David Giacometti

This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+ Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside Like prior studies (1), they found that this transport method did not […]

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Longevity Supplements, NMN, Research

Case Study on Liposomal NMN Shows Positive Impact on Triglycerides and NAD+ Levels

Posted on by Ben Johnson

“In an animal model of type 2 diabetes, the intragastric delivery of Lip-BBR via liposomes exhibited remarkable protective effects against hepatic tissue damage, steatosis, inflammation, insulin resistance, and hepatocellular enzyme imbalance.”

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Aging & Longevity, Longevity Supplements, Metabolic Health, NAD+, Research

How NAD+ Boosts ATP and What it Means for Health and Aging

Posted on by David Giacometti

Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on a vast range of age-related disorders through improving the levels of ATP. Declining ATP as we age […]

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Aging & Longevity, Metabolic Health, NAD+, NMN

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

Posted on by David Giacometti

The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potentialtherapeutic strategy to mitigate aging-related disorders in humans.

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NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Posted on by David Giacometti

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

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Aging & Longevity, Metabolic Health, NAD+, Reproductive Health, Research

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Posted on by David Giacometti

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]

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NAD+, NMN

Slc12a8 Does not Solve the Bioavailability Problem for NMN Capsules

Posted on by David Giacometti

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered because it plays a very minor […]

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