NMN & NAD+ PRECURSORS

NMN Nanoparticles Outperform Free NMN for Anti-Aging in Mice

This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model [...]

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23
Apr
NAD+ Nanoparticle Injection Decreased Blood Vessel Damage In Rats

A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth [...]

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11
Apr
Liposomal delivery of NR shows increased bioavailability

"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and READ MORE

21
Mar
Niacin, NMN, and NR Are Not The Same

While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys [...]

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14
Mar
NMN Extended Lifespan in Fast-Aging Mice

“We showed that NMN consistently extended the healthy and median lifespan of Zmpste24-/- and improved [...]

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04
Mar
Neuroprotective Effects of NAD+ Nasal Spray

"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption [...]

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26
Feb

LATEST ARTICLES

Aging & Longevity, Metabolic Health, NAD+, NMN

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

Posted on by David Giacometti

The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potentialtherapeutic strategy to mitigate aging-related disorders in humans.

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NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Posted on by David Giacometti

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

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Aging & Longevity, Metabolic Health, NAD+, Reproductive Health, Research

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Posted on by David Giacometti

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]

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NAD+, NMN

Slc12a8 Does not Solve the Bioavailability Problem for NMN Capsules

Posted on by David Giacometti

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered because it plays a very minor […]

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NAD+, NR, Reproductive Health, Research

Increased NAD+ in Bloodstream of Nursing Mice Results in Healthier, Stronger, Smarter Offspring

Posted on by David Giacometti

This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups were removed from the mothers and fed normal chow. These improvements in health and behavior persisted for […]

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Intestinal Health, Kidney, Liver & Lungs, NAD+, NMN, Research

Scientists discover SLC12a8 pathway used by NMN to restore NAD+ levels

Posted on by David Giacometti

Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered […]

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Immune System, Metabolic Health, NAD+, Neurological, Research

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Posted on by David Giacometti

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, increases NAD+ levels, reduces hunger and weight gain, and increases energy expenditure and fat burning in mice. This study shows that increased NAD+ […]

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Metabolic Health, NAD+, Research

Exogenous NAD+ Increases Metabolism

Posted on by David Giacometti

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels in the hypothalamus to normal levels. 1 The hypothalamus is the master regulator of metabolism.  Decreased levels […]

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Aging & Longevity, Metabolic Health, NAD+, NMN

NAD+ for Metabolism and Brain, NMN for the body?

Posted on by David Giacometti

Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their lifespan.

Although they have similar effect in some organs, there may be differences in the effect they have in other tissues throughout the body.

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