NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph).
Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022.
Scientists from Baylor College of Medicine in Houston studying glutathione precursors have demonstrated some of the best life extension results ever achieved in mice – increasing their lifespan by 24%.
A study published on April 11, 2022 claims that 600 mg of NMN improves strength, well-being and the biological age in people aged 40-65.
This study confirms NMN supplementation increases blood intracellular NAD levels and improves physical strength and overall health in healthy middle-aged and older men and women.
Resveratrol is a polyphenol derived from plants with antioxidant properties that have been shown to enhance the activation of the body’s own self-repair proteins, called sirtuins. When sirtuins are activated, the effect is delayed aging, which has been demonstrated in a wide spectrum of experimental models, including mammals.
CD38 Increases as We Age and Drives Down NAD+ Levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that CD38 levels increase, and that NAD+ decreases as we age. A 2016 study found that the increased levels of CD38 are a primary driver of decreasing levels of NAD+ […]
(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022. MIB-626, an […]
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]
Restoring NAD+ levels is crucial to maximize health as we age. Many supplements that decrease systemic inflammation also have direct and indirect effect on NAD+ levels. Supplements to Restore NAD+ NAD+ and NAD+ precursor supplements Increase endogenous NAD+ production Decrease NAD+ consumption in the body NAD+ and NAD+ Precursors We offer the most complete range […]
David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field of longevity research. In a recent video, titled “Dr David Sinclair – Defeating Ageing & Living Longer | Modern Wisdom Podcast 343” [The video has been made private by the uploader], Dr. Sinclair discusses the supplements he is currently […]
Stem cells – the source of tissue homeostasis In human tissue, there are various highly differentiated cells specialized to perform distinct functions. For example, there are red blood cells for oxygen delivery, muscle cells for movement, neural cells for signal transduction, etc. These cells are vital for life but they are also prone to various […]
TMG – the Insurance Policy Against Loss of Methyl Groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take glycine, specifically trimethylglycine is to counter what I think may be going on with an NAD+ booster”… […]
If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated […]