This study showed that NR supplementation protected mice from HFD-induced metabolic dysfunction, specifically through protecting mitochondrial function in the skeletal muscle.
Category Archives: NAD+
More than 240 clinical trials have been conducted to understand the potential health effects of Resveratrol. Evidence suggests Resveratrol may enhance longevity, heart health, glucose and fat metabolism, and bone health.
This study revealed a new technique to quickly, accurately, and inexpensively test blood NAD+ levels in humans to allow repeated testing throughout the day in clinical settings, and eventually at home.
Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.
A clinical trial examined Coenzyme Q10’s (CoQ10’s) effects on episodic migraines in women, finding significant reductions in migraine frequency, duration, severity. CoQ10 also reduced the levels of TNF-ɑ and CGRP, a peptide linked to migraines that promotes inflammation and pain signaling.
Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.
Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.
CoQ10 may extend its potential benefits beyond its traditional role in energy production. Emerging research suggests it could provide cardioprotective effects and reduce migraine symptoms. Moreover, its anti-inflammatory and antioxidant properties have shown promise in addressing age-related disorders and various diseases.
Oral administration of NMN (500 mg/kg) effectively preserved NAD+ tissue and plasma levels during PM exposure and protected against pulmonary fibrosis in mice.
Quercetin, a bioactive compound found in various fruits and vegetables, has attracted significant attention for its potential therapeutic effects against allergies.
NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.
A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).
A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious
MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28
Circulating NMN levels did not change significantly in either group…
There are now 12 studies published to date in humans with NMN supplementation. The previous 11 studies used oral delivery of NMN capsules, and were generally quite positive. This most recent study used a single dose of NMN by IV. Researchers were surprised to find a 75% drop in triglycerides. There haven’t been any previous […]