Category Archives: NAD+

Study Shows NR Injections Increase Muscle NAD+ in Mice, Oral Supplementation Does Not

NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.

A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).

NMN lowers Cholesterol, bodyweight, and blood pressure in 28 day trial with overweight older adults

A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious

MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28

Circulating NMN levels did not change significantly in either group…

New Research with NMN by IV Shows Much Stronger Effect Than Oral Supplementation

There are now 12 studies published to date in humans with NMN supplementation. The previous 11 studies used oral delivery of NMN capsules, and were generally quite positive. This most recent study used a single dose of NMN by IV. Researchers were surprised to find a 75% drop in triglycerides. There haven’t been any previous […]

NAD+ Reduces Mutations and Incidence of Skin Cancer

In a new study by Brown University School of Medicine, it was shown that oral nicotinamide (NAM) supplementation decreased the incidence of keratinocyte carcinoma (KC) in high-risk skin cancer patients.  NAM is converted to NAD+ in the body and it is NAD+ that is believed to be responsible for for the decrease in Keratinocyte carcinoma […]

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

NAD+ and the Hallmarks of Aging Series – Part 9: Altered Intercellular Communication

Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell). In order to work collectively and maintain the homeostasis across multiple tissues, our cells have developed multiple different ways to receive, process, and transmit information between each other, including endocrine, […]

Inhibition of CD38 Increases NAD+ Levels

CD38 Increases as We Age and Drives Down NAD+ Levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that CD38 levels increase, and that NAD+ decreases as we age. A 2016 study found that the increased levels of CD38 are a primary driver of decreasing levels of NAD+ […]

NMN Triples NAD+ Levels in Humans

(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022. MIB-626, an […]

Why Dr. Sinclair takes NMN instead of NR

There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]

NAD+ and the Hallmarks of Aging Series – Part 8: Stem Cell Exhaustion

Stem cells – the source of tissue homeostasis In human tissue, there are various highly differentiated cells specialized to perform distinct functions. For example, there are red blood cells for oxygen delivery, muscle cells for movement, neural cells for signal transduction, etc.  These cells are vital for life but they are also prone to various […]

Trimethylglycine (TMG) for Restoring Methylation, Homocysteine Levels, Heart Health, and Liver Function

TMG – the Insurance Policy Against Loss of Methyl Groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take glycine, specifically trimethylglycine is to counter what I think may be going on with an NAD+ booster”… […]