This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health in male and female mice. Effects of NMN on Lifespan and Healthspan in Aging Mice Mice were divided into two main groups based on sex and treatment: NMN group: Received NMN in drinking water (~550 mg/kg/day). Control group: Received regular […]
Tag Archives: genetics
A team of scientists from Harvard Medical School discovered a method to distinguish young cells from old and senescent cells in real time. This allowed them to quickly screen the effect of different molecules on cellular health.
Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.
The ability to repair DNA damage decreases over time, causing an accumulation of mutations that can affect cellular function, viability, and an increase in the aging process. In a new study, mice engineered to age quickly were tested to see which compounds were best at promoting DNA repair. Nicotinamide Riboside (NR) shown to increase lifespan […]
In a new study by Brown University School of Medicine, it was shown that oral nicotinamide (NAM) supplementation decreased the incidence of keratinocyte carcinoma (KC) in high-risk skin cancer patients. NAM is converted to NAD+ in the body and it is NAD+ that is believed to be responsible for for the decrease in Keratinocyte carcinoma […]
Fisetin is a flavonoid found in fruits and vegetables and has been shown to have powerful senolytic properties. In a new study, fisetin was shown to prevent immune cells from becoming senescent, allowing them to enter into a state of apoptosis or cellular suicide, a normal process at the end of a cell’s life cycle. […]
As we age, the risk for clogged arteries, brittle blood vessels, and heart failure increase. A recent study looking at the DNA in numerous individual heart cells tells the story of why this occurs Buildup of Damaged DNA and Faltering Ability to Repair Damage In a ground-breaking study spanning 0 to 82 year olds, they […]
David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field of longevity research. In a recent video, titled “Dr David Sinclair – Defeating Ageing & Living Longer | Modern Wisdom Podcast 343” [The video has been made private by the uploader], Dr. Sinclair discusses the supplements he is currently […]
Stem cells – the source of tissue homeostasis In human tissue, there are various highly differentiated cells specialized to perform distinct functions. For example, there are red blood cells for oxygen delivery, muscle cells for movement, neural cells for signal transduction, etc. These cells are vital for life but they are also prone to various […]
TMG – the Insurance Policy Against Loss of Methyl Groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take glycine, specifically trimethylglycine is to counter what I think may be going on with an NAD+ booster”… […]
Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Further, a pharmacological manipulation that mimics a state of limited nutrient availability, such as rapamycin, can extend longevity in mice (Harrison et al., 2009). In […]