This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]
Tag Archives: nmn
A new study shows that increased levels in the brain of a molecule called Slc128a, which transports NMN into cells, reduces a type of muscle decline in older adults called sarcopenia. Likewise, they showed that reducing levels of Slc128a in the brain caused the muscles to become fatigued and weakened again. Doubling Slc128a Dramatically Improved […]
A new study provides evidence that NMN administered by intraperitoneal injection protects against UV damage.
Interestingly, the effect is much stronger than in studies in which NR or NMN are administered orally.
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph).
Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022.
Two recent studies have found that inhibition of CD38 (with 78c or PCC1) increase NAD+ levels and result in significant increases in lifespan and healthspan in mice.
A study published on April 11, 2022 claims that 600 mg of NMN improves strength, well-being and the biological age in people aged 40-65.
This study confirms NMN supplementation increases blood intracellular NAD levels and improves physical strength and overall health in healthy middle-aged and older men and women.
CD38 Increases as We Age and Drives Down NAD+ Levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that CD38 levels increase, and that NAD+ decreases as we age. A 2016 study found that the increased levels of CD38 are a primary driver of decreasing levels of NAD+ […]
(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022. MIB-626, an […]
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]
David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field of longevity research. In a recent video, titled “Dr David Sinclair – Defeating Ageing & Living Longer | Modern Wisdom Podcast 343” [The video has been made private by the uploader], Dr. Sinclair discusses the supplements he is currently […]
If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated […]