NR Preserved Intestinal Lining Integrity During Excessive Alcohol Intake
“In particular, the intestine, as the main organ of ethanol absorption, is susceptible to serious injury from excess drinking.”
When mice were given alcohol without NR supplementation, it led to higher levels of intestinal contents entering their bloodstream, suggesting damage to the intestinal lining.
NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.
A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).
“But until now, it was unknown whether NR reached targeted organs like the brain to have a real therapeutic effect,” according to Christopher Martens, one of the key researchers in this study, and the director of the Delaware Center for Cognitive Aging Research.
Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.
Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver
Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR
A recent article in sciencedaily.com took some research out of context and wrote a review with a click-bait title that caused a lot of uproar as others repeated the faulty review. Here is the title of the original research: “A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link […]
The ability to repair DNA damage decreases over time, causing an accumulation of mutations that can affect cellular function, viability, and an increase in the aging process. In a new study, mice engineered to age quickly were tested to see which compounds were best at promoting DNA repair. Nicotinamide Riboside (NR) shown to increase lifespan […]
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]
If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated […]
NAD+ Precursors and Healthy Aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the substrate for enzymes such as the sirtuins. One of the hallmarks of aging is declining cellular NAD+ levels. Moreover, many studies carried out in different […]
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potentialtherapeutic strategy to mitigate aging-related disorders in humans.
Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]