“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway by which NAD+-boosting agent nicotinamide mononucleotide (NMN) regulates MSR in AD models.”
Category Archives: Neurological
This preprint investigated the neuroprotective effects of berberine pretreatment in a rat model of Parkinson’s disease.
Glycine is a non-essential amino acid that is nonetheless necessary for many health-promoting metabolic processes. It is an integral part of protiens made inside the body, a precursor for important biomolecules like glutathione and creatine, and acts as an inhibitory (calming) neurotransmitter in the central nervous system. Research strongly supports glycine’s potential to protect health […]
This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast onset of pharmacological action."
This article delves into the scientific evidence concerning NMN, SARM1 activation, and their impact on axonal health.
“NMN had the highest concentrations in breast milk among the NAD-related substances. We demonstrated, for the first time, a positive relationship between NMN concentrations in breast milk and the neurodevelopmental outcome of a child.”
“NMN exerts neuroprotective effects after SCI by the regulation of certain genes acting on signaling pathways related to neurological diseases.”
This study showed that NR (1 g/day) for 10 weeks is safe in adults with MCI and effectively increased blood levels of NAD+.
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