“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, [...]
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NMN treatment effectively revitalized aging skin in mice, enhancing both its visible appearance and underlying [...]
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“To our knowledge, this is the first report showing that NRH can reach multiple tissues [...]
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This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]
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“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]
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“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]
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In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which restored NAD+ levels in the hypothalamus to normal levels. 1
The hypothalamus is the master regulator of metabolism. Decreased levels of NAD+ are found in hypothalamus with obesity, disease and the normal aging process.
CD38 Increases as We Age and Drives Down NAD+ Levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that CD38 levels increase, and that NAD+ decreases as we age. A 2016 study found that the increased levels of CD38 are a primary driver of decreasing levels of NAD+ […]
(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022. MIB-626, an […]
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]
Restoring NAD+ levels is crucial to maximize health as we age. Many supplements that decrease systemic inflammation also have direct and indirect effect on NAD+ levels. Supplements to Restore NAD+ NAD+ and NAD+ precursor supplements Increase endogenous NAD+ production Decrease NAD+ consumption in the body NAD+ and NAD+ Precursors We offer the most complete range […]
David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field of longevity research. In a recent video, titled “Dr David Sinclair – Defeating Ageing & Living Longer | Modern Wisdom Podcast 343” [The video has been made private by the uploader], Dr. Sinclair discusses the supplements he is currently […]
Stem cells – the source of tissue homeostasis In human tissue, there are various highly differentiated cells specialized to perform distinct functions. For example, there are red blood cells for oxygen delivery, muscle cells for movement, neural cells for signal transduction, etc. These cells are vital for life but they are also prone to various […]
TMG – the Insurance Policy Against Loss of Methyl Groups TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate. “The reason I take glycine, specifically trimethylglycine is to counter what I think may be going on with an NAD+ booster”… […]
Mitochondria – More than Powerplants in Cells Mitochondria are the large organelles that exist in most human cells. They are the critical organelles that generate ATP through the respiratory chain and produce the intermediate metabolites that are essential to various cellular processes. During aging, the respiratory chain losses its efficacy and the membrane of the […]
If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health. “high doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated […]
NAD+ Precursors and Healthy Aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the substrate for enzymes such as the sirtuins. One of the hallmarks of aging is declining cellular NAD+ levels. Moreover, many studies carried out in different […]
Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Further, a pharmacological manipulation that mimics a state of limited nutrient availability, such as rapamycin, can extend longevity in mice (Harrison et al., 2009). In […]