“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway by which NAD+-boosting agent nicotinamide mononucleotide (NMN) regulates MSR in AD models.”
Tag Archives: brain health
Creatine is an amino acid derivative stored in your muscles and used to create energy for movement. Every cell in the body relies on Adenosine Triphosphate (ATP) as a source of energy that through muscle contraction, uses ATP and releases Adenosine Diphosphate (ADP). Stores of Creatine in your muscles help to quickly turn ADP back to ATP for additional energy.
This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast onset of pharmacological action."
This article delves into the scientific evidence concerning NMN, SARM1 activation, and their impact on axonal health.
This study evaluated the effects of intraperitoneal (i.p.) injections of NMN on tumor-induced cellular aging, inflammation, mitochondrial function, and survival in mice.
“NMN had the highest concentrations in breast milk among the NAD-related substances. We demonstrated, for the first time, a positive relationship between NMN concentrations in breast milk and the neurodevelopmental outcome of a child.”
This study evaluated the safety and effects of high-dose (3,000 mg) Nicotinamide Riboside (NR) supplementation in patients with Parkinson’s Disease (PD).
“These data from a community-based sample demonstrate that SWS percentage declines over time in adults 60 years and older and that greater declines are associated with the risk of future dementia.”
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