Longevity Clips

NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Posted on September 6, 2022June 16, 2023 by Ben Johnson

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

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Longevity Supplements

Oral Hyaluronic Acid: Advanced Support for Skin, Joint Health and Longevity

Posted on September 6, 2022June 16, 2023 by Ben Johnson

Supplementation with HLA may improve joint function, reduce wrinkles and even extend lifespan. What is Hyaluronic Acid? Hyaluronic acid (a.k.a. hyaluronan, HA, or HLA) is a substance naturally found in many areas of the human body including the skin, eyes, and synovial fluid of the joints. Preserves Tissue Hydration More than 50% of the […]

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Research

Increasing NMN Transporter in the Brain Reduces Age-Related Muscle Decline

Posted on September 1, 2022November 9, 2022 by David

A new study shows that increased levels in the brain of a molecule called Slc128a, which transports NMN into cells, reduces a type of muscle decline in older adults called sarcopenia. Likewise, they showed that reducing levels of Slc128a in the brain caused the muscles to become fatigued and weakened again. Doubling Slc128a Dramatically Improved […]

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Aging & Longevity, Cardiovascular, Research

Heart Disease Related to Accumulation of DNA Damage and Oxidative Stress

Posted on August 24, 2022June 16, 2023 by David

As we age, the risk for clogged arteries, brittle blood vessels, and heart failure increase. A recent study looking at the DNA in numerous individual heart cells tells the story of why this occurs Buildup of Damaged DNA and Faltering Ability to Repair Damage In a ground-breaking study spanning 0 to 82 year olds, they […]

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Longevity Supplements

Why Dr. Sinclair takes NMN instead of NR

Posted on July 3, 2022October 7, 2022 by Ben Johnson

There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]

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Aging & Longevity, NAD+, Research

NAD+ and the Hallmarks of Aging Series – Part 9: Altered Intercellular Communication

Posted on July 3, 2022June 16, 2023 by Ben Johnson

Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell). In order to work collectively and maintain the homeostasis across multiple tissues, our cells have developed multiple different ways to receive, process, and transmit information between each other, including endocrine, […]

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NMN, Skin Care

NMN Injection Protects Against UV Damage to Skin

Posted on July 3, 2022June 30, 2023 by David

A new study provides evidence that NMN administered by intraperitoneal injection protects against UV damage.

Interestingly, the effect is much stronger than in studies in which NR or NMN are administered orally.

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Longevity Supplements, Metabolic Health, Neurological, Research

Newly Found Benefits of Resveratrol in Health and Anti-aging

Posted on July 3, 2022June 30, 2023 by Ben Johnson

Resveratrol is a polyphenol derived from plants with antioxidant properties that have been shown to enhance the activation of the body’s own self-repair proteins, called sirtuins. When sirtuins are activated, the effect is delayed aging, which has been demonstrated in a wide spectrum of experimental models, including mammals.

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Longevity Supplements

600 mg of NMN Improves Endurance In People Aged 40-65

Posted on July 3, 2022June 30, 2023 by Ben Johnson

A study published on April 11, 2022 claims that 600 mg of NMN improves strength, well-being and the biological age in people aged 40-65.

This study confirms NMN supplementation increases blood intracellular NAD levels and improves physical strength and overall health in healthy middle-aged and older men and women.

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Longevity Supplements

Glutathione Precursors Increase Lifespan in Mice by 24%

Posted on July 3, 2022June 30, 2023 by Ben Johnson

Scientists from Baylor College of Medicine in Houston studying glutathione precursors have demonstrated some of the best life extension results ever achieved in mice – increasing their lifespan by 24%.

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Aging & Longevity, NAD+, Research

Inhibition of CD38 Increases NAD+ Levels, Extends Life and Healthspan in Mice

Posted on July 3, 2022June 30, 2023 by Ben Johnson

Two recent studies have found that inhibition of CD38 (with 78c or PCC1) increase NAD+ levels and result in significant increases in lifespan and healthspan in mice.

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Longevity Supplements

NMN Triples NAD+ Levels in Humans

Posted on July 3, 2022June 30, 2023 by Ben Johnson

NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph).

Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022.

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Updated list of NMN studies in humans

NMN Resveratrol synergy

intravenous nmn results

NMN & NAD+ PRECURSORS

NMN Transporters and eNAMPT: Key Regulators of NAD+ Balance in Aging

NMN Rejuvenates Skin in Aging Mice

A Novel NAD+ Precursor (NRH) Improves Glucose and Fat Metabolism in Obese Mice

NMN Protects Mitochondria and Reduces Heart Injury in Septic Mice

NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Longevity Supplements

Oral Hyaluronic Acid: Advanced Support for Skin, Joint Health and Longevity

Research

Increasing NMN Transporter in the Brain Reduces Age-Related Muscle Decline

Aging & Longevity, Cardiovascular, Research

Heart Disease Related to Accumulation of DNA Damage and Oxidative Stress

Longevity Supplements

Why Dr. Sinclair takes NMN instead of NR

Aging & Longevity, NAD+, Research

NAD+ and the Hallmarks of Aging Series – Part 9: Altered Intercellular Communication

NMN, Skin Care

NMN Injection Protects Against UV Damage to Skin

Longevity Supplements, Metabolic Health, Neurological, Research

Newly Found Benefits of Resveratrol in Health and Anti-aging

Longevity Supplements

600 mg of NMN Improves Endurance In People Aged 40-65

Longevity Supplements

Glutathione Precursors Increase Lifespan in Mice by 24%

Aging & Longevity, NAD+, Research

Inhibition of CD38 Increases NAD+ Levels, Extends Life and Healthspan in Mice

Longevity Supplements

NMN Triples NAD+ Levels in Humans

Updated list of NMN studies in humans

NMN Resveratrol synergy

intravenous nmn results

NMN & NAD+ PRECURSORS

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