NMN & NAD+ PRECURSORS

NMN Protects Mitochondria and Reduces Heart Injury in Septic Mice

This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]

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09
Dec
NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct
NMN Improved Aging Parameters in Clinical Trial

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11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug

LATEST ARTICLES

NAD+, NMN

Slc12a8 Does not Solve the Bioavailability Problem for NMN Capsules

Posted on by David Giacometti

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered because it plays a very minor […]

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NAD+, NR, Reproductive Health, Research

Increased NAD+ in Bloodstream of Nursing Mice Results in Healthier, Stronger, Smarter Offspring

Posted on by David Giacometti

This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups were removed from the mothers and fed normal chow. These improvements in health and behavior persisted for […]

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Intestinal Health, Kidney, Liver & Lungs, NAD+, NMN, Research

Scientists discover SLC12a8 pathway used by NMN to restore NAD+ levels

Posted on by David Giacometti

Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered […]

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Immune System, Metabolic Health, NAD+, Neurological, Research

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Posted on by David Giacometti

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, increases NAD+ levels, reduces hunger and weight gain, and increases energy expenditure and fat burning in mice. This study shows that increased NAD+ […]

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Metabolic Health, NAD+, Research

Exogenous NAD+ Increases Metabolism

Posted on by David Giacometti

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which  restored NAD+ levels in the hypothalamus to normal levels. 1 The hypothalamus is the master regulator of metabolism.  Decreased levels […]

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Aging & Longevity, Metabolic Health, NAD+, NMN

NAD+ for Metabolism and Brain, NMN for the body?

Posted on by David Giacometti

Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice, making them look and behave like they did when young and extending their lifespan.

Although they have similar effect in some organs, there may be differences in the effect they have in other tissues throughout the body.

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