NMN & NAD+ PRECURSORS

NMN Transporters and eNAMPT: Key Regulators of NAD+ Balance in Aging

“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, [...]

READ MORE
05
Feb
NMN Rejuvenates Skin in Aging Mice

NMN treatment effectively revitalized aging skin in mice, enhancing both its visible appearance and underlying [...]

READ MORE
16
Jan
A Novel NAD+ Precursor (NRH) Improves Glucose and Fat Metabolism in Obese Mice

“To our knowledge, this is the first report showing that NRH can reach multiple tissues [...]

READ MORE
01
Jan
NMN Protects Mitochondria and Reduces Heart Injury in Septic Mice

This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]

READ MORE
09
Dec
NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

READ MORE
04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

READ MORE
15
Oct

LATEST ARTICLES

Bone & Muscle, Cardiovascular, NAD+, NMN

Study Shows NMN Supplementation or CD38 Inhibition Restores Cardiovascular Function in Mice

Posted on by David Giacometti

CD38 Deficiency Alleviates Ang II-Induced Vascular Remodeling By Inhibiting Small Extracellular Vesicle-Mediated Vascular Smooth Muscle Cell Senescence In Mice (Lu Gan, June 2021) In this study, researchers investigated the impact of NMN supplementation and CD38 inhibition on the cardiovascular function in mice. Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It […]

Continue reading →
Aging & Longevity, Intestinal Health, Longevity Supplements, Research

Bacteria in Gastrointestional Tract Metabolize NMN and Impact NAD+ Metabolome

Posted on by David Giacometti

This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier research, and also made some surprising new findings. https://assets.researchsquare.com/files/rs-87047/v1_stamped.pdf Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, […]

Continue reading →
Aging & Longevity, Longevity Supplements, NAD+, Research

CD73 utilization shows importance of NMN to restore NAD+

Posted on by David Giacometti

This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+ Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside Like prior studies (1), they found that this transport method did not […]

Continue reading →
Longevity Supplements, NMN, Research

Case Study on Liposomal NMN Shows Positive Impact on Triglycerides and NAD+ Levels

Posted on by Ben Johnson

“In an animal model of type 2 diabetes, the intragastric delivery of Lip-BBR via liposomes exhibited remarkable protective effects against hepatic tissue damage, steatosis, inflammation, insulin resistance, and hepatocellular enzyme imbalance.”

Continue reading →
Aging & Longevity, Longevity Supplements, Metabolic Health, NAD+, Research

How NAD+ Boosts ATP and What it Means for Health and Aging

Posted on by David Giacometti

Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect not only on ageing itself but also on a vast range of age-related disorders through improving the levels of ATP. Declining ATP as we age […]

Continue reading →
Aging & Longevity, Metabolic Health, NAD+, NMN

1st NMN Human Study Demonstrates Safety and Faster Utilization than NR

Posted on by David Giacometti

The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potentialtherapeutic strategy to mitigate aging-related disorders in humans.

Continue reading →
NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Posted on by David Giacometti

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

Continue reading →
Aging & Longevity, Metabolic Health, NAD+, Reproductive Health, Research

NAD+ is the Transport Molecule Used by the Body, Not Nicotinamide Riboside

Posted on by David Giacometti

Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method being researched is providing supplements  such as Nicotinamide Riboside (NR) that the body can use to create NAD+. The chart above is from this study published in August 2019 by […]

Continue reading →
NAD+, NMN

Slc12a8 Does not Solve the Bioavailability Problem for NMN Capsules

Posted on by David Giacometti

This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells. However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered because it plays a very minor […]

Continue reading →
NAD+, NR, Reproductive Health, Research

Increased NAD+ in Bloodstream of Nursing Mice Results in Healthier, Stronger, Smarter Offspring

Posted on by David Giacometti

This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR. After 21 days, the pups were removed from the mothers and fed normal chow. These improvements in health and behavior persisted for […]

Continue reading →
Intestinal Health, Kidney, Liver & Lungs, NAD+, NMN, Research

Scientists discover SLC12a8 pathway used by NMN to restore NAD+ levels

Posted on by David Giacometti

Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells However, this enzyme is only prevalent in the small intestine of older, sicker animals and humans. The Slc12a8 enzyme was just discovered […]

Continue reading →
Immune System, Metabolic Health, NAD+, Neurological, Research

NAD+ Supplements Regulate Energy Metabolism via the Hypothalamus

Posted on by David Giacometti

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, increases NAD+ levels, reduces hunger and weight gain, and increases energy expenditure and fat burning in mice. This study shows that increased NAD+ […]

Continue reading →