A study reported new insights into NAD+ precursor dynamics using a novel method to follow NMN uptake and metabolism in cells.
Category Archives: Research
“Upon oral administration, NMN–HAP nanoparticles demonstrated prolonged circulation time and enhanced bioavailability compared with free NMN, leading to elevated plasma levels of both NAD+ and its precursor, NR.”
Hesperidin is a flavonoid, a type of plant compound that has been shown to have a wide range of health benefits. It is found primarily in citrus fruits, such as oranges, lemons, grapefruit, and limes. Hesperidin exhibits anti-inflammatory and antioxidant activity, protecting cells from two key contributors to the onset of age-related and chronic diseases: inflammation and oxidative stress.
Modern research supports the traditional uses of Ashwaganda, showing it may help reduce stress, anxiety, fatigue, improve cognitive function, boost the immune system, and help manage blood sugar levels.
“These results suggest that NMN treatment functionally ameliorated or prevented exacerbation of heart failure in p32 cardiomyocyte–specific knockout mice, thereby prolonging their lifespan.”
This study showed that Quercetin protected rats with osteoarthritis against bone and cartilage damage by reducing inflammation and modulating levels of proteins associated with cartilage health.
“Overall, the present study may shed new light on novel strategies in which NAD+ boosting therapy, including NMN supplement and CD38 inhibition, may turn out to be a promising therapeutic measure to treat patients with hypertension.”
5-hydroxytryptophan (5-HTP) is a natural substance that the body makes to produce serotonin, a neurotransmitter that helps regulate mood, sleep, appetite, and pain.
Supplementation with 5-HTP has shown to increase levels of serotonin in the body, which has potential benefits for a number of conditions.
This study showed that NR supplementation protected mice from HFD-induced metabolic dysfunction, specifically through protecting mitochondrial function in the skeletal muscle.
This study examined the effects of Apigenin on inflammation, gut barrier integrity, and the gut microbiome in mice with ulcerative colitis (UC).
More than 240 clinical trials have been conducted to understand the potential health effects of Resveratrol. Evidence suggests Resveratrol may enhance longevity, heart health, glucose and fat metabolism, and bone health.
This study revealed a new technique to quickly, accurately, and inexpensively test blood NAD+ levels in humans to allow repeated testing throughout the day in clinical settings, and eventually at home.
Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.