Palmitoylethanolamide (PEA) is a natural compound that your body produces in response to various forms of cellular damage. Its primary role is to promote homeostasis, which is the body’s ability to maintain a stable and balanced internal environment for optimal functioning and overall wellness.
Category Archives: Research
Quercetin, a bioactive compound found in various fruits and vegetables, has attracted significant attention for its potential therapeutic effects against allergies.
“Recent studies showed that BBR significantly reduced liver steatosis, improved insulin resistance, alleviated glucose and lipid metabolism disorders, and exhibited therapeutic effects on NAFLD in humans and mice.”
A recent study evaluated the therapeutic efficacy of Spermidine for blood flow recovery and blood vessel growth after artificially blocked blood flow in mice.
“Spermidine is a naturally occurring polyamine that has shown substantial evidence of anti-aging properties”
This new study found that for the first time that NMN supplementation in humans increases levels of NMN in blood plasma.
All previous studies with NMN and NR have not been able to detect measurable increase in blood levels of NMN or NR.
They also found increased levels of NAD+ and insulin levels.
NR Preserved Intestinal Lining Integrity During Excessive Alcohol Intake
“In particular, the intestine, as the main organ of ethanol absorption, is susceptible to serious injury from excess drinking.”
When mice were given alcohol without NR supplementation, it led to higher levels of intestinal contents entering their bloodstream, suggesting damage to the intestinal lining.
NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.
A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).
Dr. David Sinclair recently posted about a breakthrough study on Alpha-Ketoglutarate (AKG).
He said, “Feeding 18-month old female mice AKG reduced hair greying, frailty & extended median lifespan 10-16%."
“NMN reduced fat mass, which visibly translated into a significantly lower weight of the WAT and BAT in NMN treatment mice.”
“Several human clinical trials indicate that NR and NAM supplementation decrease the risk factors of CVDs, such as hypertension, arterial stiffness, and elevated level of low-density lipoprotein cholesterol 13,14.”
Although NMN has been proven to improve vascular dysfunction in mice, it has not been thoroughly evaluated in humans.
A new human trial using 36 healthy middle-aged participants was recently published showing positive efficacy for NMN. In this 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial, it was shown that just 125mg of NMN twice per day reduced blood vessel stiffness and significantly decreased diastolic blood pressure in participants with elevated glucose levels. (1) NAD+ […]
A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious
MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28
Circulating NMN levels did not change significantly in either group…