“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, [...]
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NMN treatment effectively revitalized aging skin in mice, enhancing both its visible appearance and underlying [...]
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“To our knowledge, this is the first report showing that NRH can reach multiple tissues [...]
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This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]
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“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]
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“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]
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5-hydroxytryptophan (5-HTP) is a natural substance that the body makes to produce serotonin, a neurotransmitter that helps regulate mood, sleep, appetite, and pain.
Supplementation with 5-HTP has shown to increase levels of serotonin in the body, which has potential benefits for a number of conditions.
This study showed that NR supplementation protected mice from HFD-induced metabolic dysfunction, specifically through protecting mitochondrial function in the skeletal muscle.
This study examined the effects of Apigenin on inflammation, gut barrier integrity, and the gut microbiome in mice with ulcerative colitis (UC).
More than 240 clinical trials have been conducted to understand the potential health effects of Resveratrol. Evidence suggests Resveratrol may enhance longevity, heart health, glucose and fat metabolism, and bone health.
This study revealed a new technique to quickly, accurately, and inexpensively test blood NAD+ levels in humans to allow repeated testing throughout the day in clinical settings, and eventually at home.
Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.
This study showed that P.E.A. protected mice from HFD-induced anxiety-like behavior and inflammation. “As our data demonstrated, the blunted synthesis of pro-inflammatory cytokines by PEA can stop this vicious cycle among brain immune cells, limiting the progression of enduring neuroinflammation.”
A clinical trial examined Coenzyme Q10’s (CoQ10’s) effects on episodic migraines in women, finding significant reductions in migraine frequency, duration, severity. CoQ10 also reduced the levels of TNF-ɑ and CGRP, a peptide linked to migraines that promotes inflammation and pain signaling.
Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.
Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.
CoQ10 may extend its potential benefits beyond its traditional role in energy production. Emerging research suggests it could provide cardioprotective effects and reduce migraine symptoms. Moreover, its anti-inflammatory and antioxidant properties have shown promise in addressing age-related disorders and various diseases.
Oral administration of NMN (500 mg/kg) effectively preserved NAD+ tissue and plasma levels during PM exposure and protected against pulmonary fibrosis in mice.
