NMN & NAD+ PRECURSORS

NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct
NMN Improved Aging Parameters in Clinical Trial

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11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug
NMN Enhances Cellular Protection and Cognitive Function in Alzheimer’s Disease Mice

[...]

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20
Aug

LATEST ARTICLES

Aging & Longevity, Immune System, Kidney, Liver & Lungs, NMN, Research

Study Finds Liposomal Berberine Improves Glucose, Lipids, and Inflammation in Rats

Posted on by Rebecca Crews

“In an animal model of type 2 diabetes, the intragastric delivery of Lip-BBR via liposomes exhibited remarkable protective effects against hepatic tissue damage, steatosis, inflammation, insulin resistance, and hepatocellular enzyme imbalance.”

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Research

Study Demonstrates Age Reversal through Cellular Reprogramming with Chemical Cocktails – David Sinclair

Posted on by Ben Johnson

A team of scientists from Harvard Medical School discovered a method to distinguish young cells from old and senescent cells in real time.  This allowed them to quickly screen the effect of different molecules on cellular health.

Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.

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Aging & Longevity, Immune System, Intestinal Health, Lifestyle, Diet & Fitness, Longevity Supplements, Metabolic Health, Neurological, Research

The Comprehensive Effects of Berberine for Metabolic Health

Posted on by Rebecca Crews

Berberine is a bioactive compound found in many plants, including goldenseal, Oregon grape, and barberry. It has been recognized for its health benefits for centuries, with its earliest known therapeutic use dating back to A.D. 200.  Today, Berberine continues to be an exciting focus of health and wellness research, with many studies investigating its potential for maintaining metabolic health.

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Aging & Longevity, Immune System, Intestinal Health, Longevity Supplements, Metabolic Health, Neurological, Research

Palmitoylethanolamide (PEA) in Pain Relief, Gut Health, and Neuroprotection

Posted on by Rebecca Crews

Palmitoylethanolamide (PEA) is a natural compound that your body produces in response to various forms of cellular damage. Its primary role is to promote homeostasis, which is the body’s ability to maintain a stable and balanced internal environment for optimal functioning and overall wellness. 

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Aging & Longevity, Immune System, Kidney, Liver & Lungs, Longevity Supplements, Metabolic Health, NAD+, Research

Therapeutic Potential of Quercetin in Allergy Management and Inflammation

Posted on by Rebecca Crews

Quercetin, a bioactive compound found in various fruits and vegetables, has attracted significant attention for its potential therapeutic effects against allergies. 

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Kidney, Liver & Lungs, Longevity Supplements, Metabolic Health, Research

Study Finds Berberine Improves Obesity, Glucose, Lipids, & Liver Health in Mice

Posted on by Rebecca Crews

“Recent studies showed that BBR significantly reduced liver steatosis, improved insulin resistance, alleviated glucose and lipid metabolism disorders, and exhibited therapeutic effects on NAFLD in humans and mice.”

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Cardiovascular, Longevity Supplements, Research

Study Shows Spermidine Enhances Blood Flow Recovery and Promotes Blood Vessel Generation in Aged Mice

Posted on by Rebecca Crews

A recent study evaluated the therapeutic efficacy of Spermidine for blood flow recovery and blood vessel growth after artificially blocked blood flow in mice.

“Spermidine is a naturally occurring polyamine that has shown substantial evidence of anti-aging properties”

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Metabolic Health, NMN, Research

Nicotinamide Mononucleotide (NMN) Increases Plasma NMN and Insulin Levels in Healthy Subjects

Posted on by Ben Johnson

This new study found that for the first time that NMN supplementation in humans increases levels of NMN in blood plasma.

All previous studies with NMN and NR have not been able to detect measurable increase in blood levels of NMN or NR.

They also found increased levels of NAD+ and insulin levels.

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Intestinal Health, Lifestyle, Diet & Fitness, NR, Research

Study Shows NR Protects the Intestine From Damage Caused by Excessive Alcohol Intake

Posted on by Rebecca Crews

NR Preserved Intestinal Lining Integrity During Excessive Alcohol Intake

“In particular, the intestine, as the main organ of ethanol absorption, is susceptible to serious injury from excess drinking.”

When mice were given alcohol without NR supplementation, it led to higher levels of intestinal contents entering their bloodstream, suggesting damage to the intestinal lining.

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Aging & Longevity, Bone & Muscle, NAD+, NMN, NR, Research

Study Shows NR Injections Increase Muscle NAD+ in Mice, Oral Supplementation Does Not

Posted on by Ben Johnson

NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.

A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).

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