Category Archives: Aging & Longevity

The Science Behind 5-Hydroxytryptophan (5-HTP)

5-hydroxytryptophan (5-HTP) is a natural substance that the body makes to produce serotonin, a neurotransmitter that helps regulate mood, sleep, appetite, and pain.

Supplementation with 5-HTP has shown to increase levels of serotonin in the body, which has potential benefits for a number of conditions.

Study Shows NR Improves Glucose, Lipids, And Body Composition in Mice On A High-Fat Diet

This study showed that NR supplementation protected mice from HFD-induced metabolic dysfunction, specifically through protecting mitochondrial function in the skeletal muscle. 

Apigenin Balances the Gut Microbiome and Improves Ulcerative Colitis in Mice

This study examined the effects of Apigenin on inflammation, gut barrier integrity, and the gut microbiome in mice with ulcerative colitis (UC). 

The Role of Resveratrol in Healthy Aging and Metabolism

More than  240 clinical trials have been conducted to understand the potential health effects of Resveratrol. Evidence suggests Resveratrol may enhance longevity, heart health, glucose and fat metabolism, and bone health.

Study Reveals New Technique to Quickly and Accurately Measure Blood NAD+ Levels

This study revealed a new technique to quickly, accurately, and inexpensively test blood NAD+ levels in humans to allow repeated testing throughout the day in clinical settings, and eventually at home.
Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.

Palmitoylethanolamide (P.E.A.) Reduces Inflammation and Anxiety in Obese Mice

This study showed that P.E.A. protected mice from HFD-induced anxiety-like behavior and inflammation. “As our data demonstrated, the blunted synthesis of pro-inflammatory cytokines by PEA can stop this vicious cycle among brain immune cells, limiting the progression of enduring neuroinflammation.”

Coenzyme Q10 and Migraine Relief

A clinical trial examined Coenzyme Q10’s (CoQ10’s) effects on episodic migraines in women, finding significant reductions in migraine frequency, duration, severity. CoQ10 also reduced the levels of TNF-ɑ and CGRP, a peptide linked to migraines that promotes inflammation and pain signaling. 

Anti-Aging Effects of NMN – Human Clinical Trials Review

Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.

Study Shows Resveratrol Preserves Muscle Health in Aged Mice

Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.

Coenzyme Q10 in Aging, Heart Health, and Fertility

CoQ10 may extend its potential benefits beyond its traditional role in energy production. Emerging research suggests it could provide cardioprotective effects and reduce migraine symptoms. Moreover, its anti-inflammatory and antioxidant properties have shown promise in addressing age-related disorders and various diseases.

Study Shows NMN Protects Against Lung Damage in Mice

Oral administration of NMN (500 mg/kg) effectively preserved NAD+ tissue and plasma levels during PM exposure and protected against pulmonary fibrosis in mice.

Study Finds Liposomal Berberine Improves Glucose, Lipids, and Inflammation in Rats

“In an animal model of type 2 diabetes, the intragastric delivery of Lip-BBR via liposomes exhibited remarkable protective effects against hepatic tissue damage, steatosis, inflammation, insulin resistance, and hepatocellular enzyme imbalance.”