“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, [...]
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NMN treatment effectively revitalized aging skin in mice, enhancing both its visible appearance and underlying [...]
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“To our knowledge, this is the first report showing that NRH can reach multiple tissues [...]
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This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]
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“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]
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“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]
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“Several human clinical trials indicate that NR and NAM supplementation decrease the risk factors of CVDs, such as hypertension, arterial stiffness, and elevated level of low-density lipoprotein cholesterol 13,14.”
Although NMN has been proven to improve vascular dysfunction in mice, it has not been thoroughly evaluated in humans.
In October, 2021 Chromadex did a study on twenty-two NMN brands having the highest market share on Amazon and found that only 14% had NMN content at or above the claims on their label.
A whopping 64% had less than 1% of the NMN it claimed on the label and 14% had ZERO NNM whatsoever.
A new human trial using 36 healthy middle-aged participants was recently published showing positive efficacy for NMN. In this 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial, it was shown that just 125mg of NMN twice per day reduced blood vessel stiffness and significantly decreased diastolic blood pressure in participants with elevated glucose levels. (1) NAD+ […]
A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious
MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28
Circulating NMN levels did not change significantly in either group…
Reduction in All-Cause Mortality Correlates with Green Tea Consumption.
Numerous large-scale studies with over 300,000+ participants have demonstrated that green tea consumption is associated with a significant decrease in all-cause mortality.
Studies of this length and magnitude are rare.
Green Tea: A Brief Overview Green tea is a popular beverage that has been consumed for thousands of years, originating in China and spreading throughout the world. It is made from the leaves of Camellia sinensis, a species of plant native to Asia. Unlike black and oolong tea, which are made from fermented leaves, green […]
The results showed that Resveratrol intake significantly lowered cholesterol and blood glucose levels (HbA1c, total cholesterol, LDL and HDL).
“These results suggest that Resveratrol (RSV) has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of Resveratrol intake is for obese and diabetic patients.”
Resveratrol, a naturally occurring compound found in grapes, berries, and other plants, has been the subject of numerous studies for its potential health benefits. It is known for its antioxidant, anti-inflammatory, and cardiovascular properties. In recent years, many human clinical trials have been conducted to investigate the effects of resveratrol on human health, including […]
A new NMN human trial using 80 middle-aged healthy adults showed that NMN supplementation was both safe and well tolerated. It also showed that NMN significantly raised NAD+ blood levels, increased endurance, and benefited bioage. Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels are known to decline […]
Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.
Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver
Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR
Studies have shown the ability of NMN to elevate systemic levels of NAD+ in humans and ameliorate many of the diseases of old age. In a new study on dogs, NMN was shown to be safe and to have similar efficacy as in humans. Dog and human NAD+ levels both decline with age Dogs have […]
A recent article in sciencedaily.com took some research out of context and wrote a review with a click-bait title that caused a lot of uproar as others repeated the faulty review. Here is the title of the original research: “A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link […]