NMN & NAD+ PRECURSORS

NMN Protects Mitochondria and Reduces Heart Injury in Septic Mice

This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]

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09
Dec
NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct
NMN Improved Aging Parameters in Clinical Trial

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11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug

LATEST ARTICLES

Lifestyle, Diet & Fitness, NMN, Research

NMN Human Trial Shows Increased Endurance, NAD+ Blood Levels, and Benefits to Bioage

Posted on by David

A new NMN human trial using 80 middle-aged healthy adults showed that NMN supplementation was both safe and well tolerated.  It also showed that NMN significantly raised NAD+ blood levels, increased endurance, and benefited bioage. Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels are known to decline […]

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Intestinal Health, NR, Research

NAD Precursors Cycle Between Host Tissues and the Gut Microbiome

Posted on by David Giacometti

Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.

Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver

Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR

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Aging & Longevity, NR

Does NR Cause Cancer? Response to A Recent Article

Posted on by David Giacometti

  A recent article in sciencedaily.com took some research out of context and wrote a review with a click-bait title that caused a lot of uproar as others repeated the faulty review. Here is the title of the original research: “A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link […]

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Bone & Muscle, Cardiovascular, Longevity Supplements, Research

NMN and Resveratrol Work Synergistically to boost NAD+ in Heart and Skeletal Muscle

Posted on by David

A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+ levels in both heart and skeletal muscle tissues in mice. Combination treatments shown to boost efficacy It is becoming more common to treat age-related diseases with anti-aging cocktails, including NAD+ or NMN to boost efficacy.  NMN has been shown […]

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Aging & Longevity, NAD+, NMN

New Research with NMN by IV Shows Much Stronger Effect Than Oral Supplementation

Posted on by David Giacometti

There are now 12 studies published to date in humans with NMN supplementation. The previous 11 studies used oral delivery of NMN capsules, and were generally quite positive. This most recent study used a single dose of NMN by IV. Researchers were surprised to find a 75% drop in triglycerides. There haven’t been any previous […]

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Research

Intravenous NMN Results in Massive Decrease in Blood Triglyceride Levels

Posted on by David

Previous human clinical trials have shown that NAD+ levels can be safely and efficiently replenished by oral NMN supplementation. Until a recent study, however, the safety and efficacy of intravenous NMN had not been firmly established. Intravenous NMN shown to be safe and effective Using 10 healthy volunteers, results indicated that intravenous NMN is both […]

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Longevity Supplements, NR, Research

NR Shows Ability to Promote DNA Repair and Increase Lifespan by 25% in Mice

Posted on by David

The ability to repair DNA damage decreases over time, causing an accumulation of mutations that can affect cellular function, viability, and an increase in the aging process.  In a new study, mice engineered to age quickly were tested to see which compounds were best at promoting DNA repair. Nicotinamide Riboside (NR) shown to increase lifespan […]

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Aging & Longevity, Longevity Supplements, Research

Recent Research on Resveratrol Shows Potential Anti-Aging Benefits

Posted on by David Giacometti

New Research Shows Resveratrol Can Help Prevent Muscle Loss & Senescence in Mice Resveratrol is a heavily studied anti-aging polyphenol packed with health benefits. To date, the compound has been shown to have antioxidant, anti-inflammatory, and anti-senescence effects. A recent study has shown that Resveratrol can prevent muscle atrophy and senescence in mice. The study […]

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Lifestyle, Diet & Fitness

Exercise Increases Blood Vessel Growth, Density, and Benefits Aging Muscle

Posted on by David

New studies are showing the benefits of exercise on blood vessel growth and aging muscle.  The loss of muscle tissue, called sarcopenia, is a natural part of the aging process.  These new studies show that steady exercise can help to overcome the loss of muscle tissue well into later years. Loss of muscle tissue starts […]

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NAD+, Research, Skin Care

NAD+ Reduces Mutations and Incidence of Skin Cancer

Posted on by David

In a new study by Brown University School of Medicine, it was shown that oral nicotinamide (NAM) supplementation decreased the incidence of keratinocyte carcinoma (KC) in high-risk skin cancer patients.  NAM is converted to NAD+ in the body and it is NAD+ that is believed to be responsible for for the decrease in Keratinocyte carcinoma […]

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Longevity Supplements

Several Health Benefits and Medicinal Uses of Crocin of Saffron

Posted on by Ben Johnson
Free Red Saffron Spice on Brown Wooden Spoon Stock Photo

    Saffron is one of the most expensive spices in the world, with a costly production process. The spice comes from the flower saffron crocus flower or Crocus sativus. The thread-like structures of the flower called stigma give saffron its name. Crocin is the most chemically active component of saffron and one of its […]

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