Oral administration of NMN (500 mg/kg) effectively preserved NAD+ tissue and plasma levels during PM exposure and protected against pulmonary fibrosis in mice.
Category Archives: Research
A team of scientists from Harvard Medical School discovered a method to distinguish young cells from old and senescent cells in real time. This allowed them to quickly screen the effect of different molecules on cellular health.
Using this method, they were able to identify 6 different combinations of molecules that can be used to “reset” the age of cells to a youthful, healthy state.
Berberine is a bioactive compound found in many plants, including goldenseal, Oregon grape, and barberry. It has been recognized for its health benefits for centuries, with its earliest known therapeutic use dating back to A.D. 200. Today, Berberine continues to be an exciting focus of health and wellness research, with many studies investigating its potential for maintaining metabolic health.
Palmitoylethanolamide (PEA) is a natural compound that your body produces in response to various forms of cellular damage. Its primary role is to promote homeostasis, which is the body’s ability to maintain a stable and balanced internal environment for optimal functioning and overall wellness.
Quercetin, a bioactive compound found in various fruits and vegetables, has attracted significant attention for its potential therapeutic effects against allergies.
“Recent studies showed that BBR significantly reduced liver steatosis, improved insulin resistance, alleviated glucose and lipid metabolism disorders, and exhibited therapeutic effects on NAFLD in humans and mice.”
A recent study evaluated the therapeutic efficacy of Spermidine for blood flow recovery and blood vessel growth after artificially blocked blood flow in mice.
“Spermidine is a naturally occurring polyamine that has shown substantial evidence of anti-aging properties”
This new study found that for the first time that NMN supplementation in humans increases levels of NMN in blood plasma.
All previous studies with NMN and NR have not been able to detect measurable increase in blood levels of NMN or NR.
They also found increased levels of NAD+ and insulin levels.
NR Preserved Intestinal Lining Integrity During Excessive Alcohol Intake
“In particular, the intestine, as the main organ of ethanol absorption, is susceptible to serious injury from excess drinking.”
When mice were given alcohol without NR supplementation, it led to higher levels of intestinal contents entering their bloodstream, suggesting damage to the intestinal lining.
NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue.
A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration failed to increase NAD+ levels compared to the control group (figure A).
Dr. David Sinclair recently posted about a breakthrough study on Alpha-Ketoglutarate (AKG).
He said, “Feeding 18-month old female mice AKG reduced hair greying, frailty & extended median lifespan 10-16%."