A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious
MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28
Circulating NMN levels did not change significantly in either group…
Category Archives: Research
Reduction in All-Cause Mortality Correlates with Green Tea Consumption.
Numerous large-scale studies with over 300,000+ participants have demonstrated that green tea consumption is associated with a significant decrease in all-cause mortality.
Studies of this length and magnitude are rare.
Green Tea: A Brief Overview Green tea is a popular beverage that has been consumed for thousands of years, originating in China and spreading throughout the world. It is made from the leaves of Camellia sinensis, a species of plant native to Asia. Unlike black and oolong tea, which are made from fermented leaves, green […]
The results showed that Resveratrol intake significantly lowered cholesterol and blood glucose levels (HbA1c, total cholesterol, LDL and HDL).
“These results suggest that Resveratrol (RSV) has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of Resveratrol intake is for obese and diabetic patients.”
Resveratrol, a naturally occurring compound found in grapes, berries, and other plants, has been the subject of numerous studies for its potential health benefits. It is known for its antioxidant, anti-inflammatory, and cardiovascular properties. In recent years, many human clinical trials have been conducted to investigate the effects of resveratrol on human health, including […]
A new NMN human trial using 80 middle-aged healthy adults showed that NMN supplementation was both safe and well tolerated. It also showed that NMN significantly raised NAD+ blood levels, increased endurance, and benefited bioage. Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels are known to decline […]
Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.
Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver
Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR
A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+ levels in both heart and skeletal muscle tissues in mice. Combination treatments shown to boost efficacy It is becoming more common to treat age-related diseases with anti-aging cocktails, including NAD+ or NMN to boost efficacy. NMN has been shown […]
Previous human clinical trials have shown that NAD+ levels can be safely and efficiently replenished by oral NMN supplementation. Until a recent study, however, the safety and efficacy of intravenous NMN had not been firmly established. Intravenous NMN shown to be safe and effective Using 10 healthy volunteers, results indicated that intravenous NMN is both […]
The ability to repair DNA damage decreases over time, causing an accumulation of mutations that can affect cellular function, viability, and an increase in the aging process. In a new study, mice engineered to age quickly were tested to see which compounds were best at promoting DNA repair. Nicotinamide Riboside (NR) shown to increase lifespan […]
New Research Shows Resveratrol Can Help Prevent Muscle Loss & Senescence in Mice Resveratrol is a heavily studied anti-aging polyphenol packed with health benefits. To date, the compound has been shown to have antioxidant, anti-inflammatory, and anti-senescence effects. A recent study has shown that Resveratrol can prevent muscle atrophy and senescence in mice. The study […]
In a new study by Brown University School of Medicine, it was shown that oral nicotinamide (NAM) supplementation decreased the incidence of keratinocyte carcinoma (KC) in high-risk skin cancer patients. NAM is converted to NAD+ in the body and it is NAD+ that is believed to be responsible for for the decrease in Keratinocyte carcinoma […]