“NMN reduced fat mass, which visibly translated into a significantly lower weight of the WAT and BAT in NMN treatment mice.”
Category Archives: Research
“Several human clinical trials indicate that NR and NAM supplementation decrease the risk factors of CVDs, such as hypertension, arterial stiffness, and elevated level of low-density lipoprotein cholesterol 13,14.”
Although NMN has been proven to improve vascular dysfunction in mice, it has not been thoroughly evaluated in humans.
A new human trial using 36 healthy middle-aged participants was recently published showing positive efficacy for NMN. In this 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial, it was shown that just 125mg of NMN twice per day reduced blood vessel stiffness and significantly decreased diastolic blood pressure in participants with elevated glucose levels. (1) NAD+ […]
A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious
MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28
Circulating NMN levels did not change significantly in either group…
Reduction in All-Cause Mortality Correlates with Green Tea Consumption.
Numerous large-scale studies with over 300,000+ participants have demonstrated that green tea consumption is associated with a significant decrease in all-cause mortality.
Studies of this length and magnitude are rare.
Green Tea: A Brief Overview Green tea is a popular beverage that has been consumed for thousands of years, originating in China and spreading throughout the world. It is made from the leaves of Camellia sinensis, a species of plant native to Asia. Unlike black and oolong tea, which are made from fermented leaves, green […]
The results showed that Resveratrol intake significantly lowered cholesterol and blood glucose levels (HbA1c, total cholesterol, LDL and HDL).
“These results suggest that Resveratrol (RSV) has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of Resveratrol intake is for obese and diabetic patients.”
Resveratrol, a naturally occurring compound found in grapes, berries, and other plants, has been the subject of numerous studies for its potential health benefits. It is known for its antioxidant, anti-inflammatory, and cardiovascular properties. In recent years, many human clinical trials have been conducted to investigate the effects of resveratrol on human health, including […]
A new NMN human trial using 80 middle-aged healthy adults showed that NMN supplementation was both safe and well tolerated. It also showed that NMN significantly raised NAD+ blood levels, increased endurance, and benefited bioage. Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels are known to decline […]
Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.
Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver
Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR
A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+ levels in both heart and skeletal muscle tissues in mice. Combination treatments shown to boost efficacy It is becoming more common to treat age-related diseases with anti-aging cocktails, including NAD+ or NMN to boost efficacy. NMN has been shown […]
Previous human clinical trials have shown that NAD+ levels can be safely and efficiently replenished by oral NMN supplementation. Until a recent study, however, the safety and efficacy of intravenous NMN had not been firmly established. Intravenous NMN shown to be safe and effective Using 10 healthy volunteers, results indicated that intravenous NMN is both […]