NMN & NAD+ PRECURSORS

NMN Transporters and eNAMPT: Key Regulators of NAD+ Balance in Aging

“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, [...]

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05
Feb
NMN Rejuvenates Skin in Aging Mice

NMN treatment effectively revitalized aging skin in mice, enhancing both its visible appearance and underlying [...]

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16
Jan
A Novel NAD+ Precursor (NRH) Improves Glucose and Fat Metabolism in Obese Mice

“To our knowledge, this is the first report showing that NRH can reach multiple tissues [...]

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01
Jan
NMN Protects Mitochondria and Reduces Heart Injury in Septic Mice

This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]

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09
Dec
NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct

LATEST ARTICLES

Bone & Muscle, Cardiovascular, Longevity Supplements, Research

NMN and Resveratrol Work Synergistically to boost NAD+ in Heart and Skeletal Muscle

Posted on by David

A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+ levels in both heart and skeletal muscle tissues in mice. Combination treatments shown to boost efficacy It is becoming more common to treat age-related diseases with anti-aging cocktails, including NAD+ or NMN to boost efficacy.  NMN has been shown […]

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Aging & Longevity, NAD+, NMN

New Research with NMN by IV Shows Much Stronger Effect Than Oral Supplementation

Posted on by David Giacometti

There are now 12 studies published to date in humans with NMN supplementation. The previous 11 studies used oral delivery of NMN capsules, and were generally quite positive. This most recent study used a single dose of NMN by IV. Researchers were surprised to find a 75% drop in triglycerides. There haven’t been any previous […]

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Research

Intravenous NMN Results in Massive Decrease in Blood Triglyceride Levels

Posted on by David

Previous human clinical trials have shown that NAD+ levels can be safely and efficiently replenished by oral NMN supplementation. Until a recent study, however, the safety and efficacy of intravenous NMN had not been firmly established. Intravenous NMN shown to be safe and effective Using 10 healthy volunteers, results indicated that intravenous NMN is both […]

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Longevity Supplements, NR, Research

NR Shows Ability to Promote DNA Repair and Increase Lifespan by 25% in Mice

Posted on by David

The ability to repair DNA damage decreases over time, causing an accumulation of mutations that can affect cellular function, viability, and an increase in the aging process.  In a new study, mice engineered to age quickly were tested to see which compounds were best at promoting DNA repair. Nicotinamide Riboside (NR) shown to increase lifespan […]

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Aging & Longevity, Longevity Supplements, Research

Recent Research on Resveratrol Shows Potential Anti-Aging Benefits

Posted on by David Giacometti

New Research Shows Resveratrol Can Help Prevent Muscle Loss & Senescence in Mice Resveratrol is a heavily studied anti-aging polyphenol packed with health benefits. To date, the compound has been shown to have antioxidant, anti-inflammatory, and anti-senescence effects. A recent study has shown that Resveratrol can prevent muscle atrophy and senescence in mice. The study […]

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Lifestyle, Diet & Fitness

Exercise Increases Blood Vessel Growth, Density, and Benefits Aging Muscle

Posted on by David

New studies are showing the benefits of exercise on blood vessel growth and aging muscle.  The loss of muscle tissue, called sarcopenia, is a natural part of the aging process.  These new studies show that steady exercise can help to overcome the loss of muscle tissue well into later years. Loss of muscle tissue starts […]

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NAD+, Research, Skin Care

NAD+ Reduces Mutations and Incidence of Skin Cancer

Posted on by David

In a new study by Brown University School of Medicine, it was shown that oral nicotinamide (NAM) supplementation decreased the incidence of keratinocyte carcinoma (KC) in high-risk skin cancer patients.  NAM is converted to NAD+ in the body and it is NAD+ that is believed to be responsible for for the decrease in Keratinocyte carcinoma […]

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Longevity Supplements

Several Health Benefits and Medicinal Uses of Crocin of Saffron

Posted on by Ben Johnson
Free Red Saffron Spice on Brown Wooden Spoon Stock Photo

    Saffron is one of the most expensive spices in the world, with a costly production process. The spice comes from the flower saffron crocus flower or Crocus sativus. The thread-like structures of the flower called stigma give saffron its name. Crocin is the most chemically active component of saffron and one of its […]

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Longevity Supplements, Research

All About Shilajit And Its Medicinal Use

Posted on by Ben Johnson
Lens, Finger, Hand, Camera lens, Cameras & optics,

Shilajit is a tar-like sticky black substance found mainly in mountainous regions. It is primarily found in the Himalayas and is vastly popular in South Asia. Shilajit has a range of benefits associated with it. It is quite famous for its boosting effects on male sexual wellness and fertility. You can see the dark color […]

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Bone & Muscle, Longevity Supplements, Research

Resveratrol Prevents Skeletal Muscle Atrophy and Senescence

Posted on by David

Resveratrol (RSV) is a natural polyphenolic compound with antioxidant, anti-inflammatory, and anti-senescence and antitumor effects.  A new study investigated the effects of resveratrol (RSV) on cigarette smoke (CS)-induced skeletal muscle atrophy and cellular senescence in mice.   Thirty-two male mice were randomly divided into four groups: the control group (N), the resveratrol group (RSV), the emphysema […]

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Aging & Longevity, Longevity Supplements

Fisetin Effectively Eliminates Senescent Cells and Restores Stem Cells

Posted on by David

Fisetin is a flavonoid found in fruits and vegetables and has been shown to have powerful senolytic properties.  In a new study, fisetin was shown to prevent immune cells from becoming senescent, allowing them to enter into a state of apoptosis or cellular suicide, a normal process at the end of a cell’s life cycle. […]

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Longevity Supplements

NMN restores kidney function and prevents kidney damage

Posted on by David

Use of NMN supplements was shown to activate Sirtuin-1, one of the body’s self repair enzymes, to repair kidney damage and restore kidney function in mice. (1) Kidney damage accumulates with age As we age, we accumulate kidney scarring and tissue hardening, which can impede the kidneys ability to filter proteins in the blood and […]

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