NMN & NAD+ PRECURSORS

NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct
NMN Improved Aging Parameters in Clinical Trial

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11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug
NMN Enhances Cellular Protection and Cognitive Function in Alzheimer’s Disease Mice

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20
Aug

LATEST ARTICLES

Longevity Supplements

NMN restores kidney function and prevents kidney damage

Posted on by David

Use of NMN supplements was shown to activate Sirtuin-1, one of the body’s self repair enzymes, to repair kidney damage and restore kidney function in mice. (1) Kidney damage accumulates with age As we age, we accumulate kidney scarring and tissue hardening, which can impede the kidneys ability to filter proteins in the blood and […]

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NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Posted on by Ben Johnson

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

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Longevity Supplements

Oral Hyaluronic Acid: Advanced Support for Skin, Joint Health and Longevity

Posted on by Ben Johnson

  Supplementation with HLA may improve joint function, reduce wrinkles and even extend lifespan. What is Hyaluronic Acid? Hyaluronic acid (a.k.a. hyaluronan, HA, or HLA) is a substance naturally found in many areas of the human body including the skin, eyes, and synovial fluid of the joints. Preserves Tissue Hydration More than 50% of the […]

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Research

Increasing NMN Transporter in the Brain Reduces Age-Related Muscle Decline

Posted on by David

A new study shows that increased levels in the brain of a molecule called Slc128a, which transports NMN into cells, reduces a type of muscle decline in older adults called sarcopenia. Likewise, they showed that reducing levels of Slc128a in the brain caused the muscles to become fatigued and weakened again. Doubling Slc128a Dramatically Improved […]

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Aging & Longevity, Cardiovascular, Research

Heart Disease Related to Accumulation of DNA Damage and Oxidative Stress

Posted on by David

As we age, the risk for clogged arteries, brittle blood vessels, and heart failure increase. A recent study looking at the DNA in numerous individual heart cells tells the story of why this occurs Buildup of Damaged DNA and Faltering Ability to Repair Damage In a ground-breaking study spanning 0 to 82 year olds, they […]

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Longevity Supplements

Why Dr. Sinclair takes NMN instead of NR

Posted on by Ben Johnson

There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]

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Aging & Longevity, NAD+, Research

NAD+ and the Hallmarks of Aging Series – Part 9: Altered Intercellular Communication

Posted on by Ben Johnson

Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell). In order to work collectively and maintain the homeostasis across multiple tissues, our cells have developed multiple different ways to receive, process, and transmit information between each other, including endocrine, […]

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Longevity Supplements, Metabolic Health, Neurological, Research

Newly Found Benefits of Resveratrol in Health and Anti-aging

Posted on by Ben Johnson

Resveratrol is a polyphenol derived from plants with antioxidant properties that have been shown to enhance the activation of the body’s own self-repair proteins, called sirtuins. When sirtuins are activated, the effect is delayed aging, which has been demonstrated in a wide spectrum of experimental models, including mammals.

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