NMN & NAD+ PRECURSORS

NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug
NMN Enhances Cellular Protection and Cognitive Function in Alzheimer’s Disease Mice

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20
Aug
NMN Administration Route Impacts Metabolism and Efficacy

This research reviews the current evidence on NMN metabolism and compares the effects of different [...]

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28
Jun
NR IV Exhibits Faster NAD+ Rise and Better Tolerability in Humans

“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was [...]

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24
Jun
Large Variation Between Individuals in Response to NMN Supplementation

“Because of the high interindividual variability of the NADΔ after NMN supplementation, monitoring NAD concentration [...]

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03
Jun

LATEST ARTICLES

Longevity Supplements

Why Dr. Sinclair takes NMN instead of NR

Posted on by Ben Johnson

There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]

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Aging & Longevity, NAD+, Research

NAD+ and the Hallmarks of Aging Series – Part 9: Altered Intercellular Communication

Posted on by Ben Johnson

Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell). In order to work collectively and maintain the homeostasis across multiple tissues, our cells have developed multiple different ways to receive, process, and transmit information between each other, including endocrine, […]

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Longevity Supplements, Metabolic Health, Neurological, Research

Newly Found Benefits of Resveratrol in Health and Anti-aging

Posted on by Ben Johnson

Resveratrol is a polyphenol derived from plants with antioxidant properties that have been shown to enhance the activation of the body’s own self-repair proteins, called sirtuins. When sirtuins are activated, the effect is delayed aging, which has been demonstrated in a wide spectrum of experimental models, including mammals.

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Aging & Longevity, Longevity Supplements, NAD+

Inhibition of CD38 Increases NAD+ Levels

Posted on by David Giacometti

CD38 Increases as We Age and Drives Down NAD+ Levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that CD38 levels increase, and that NAD+ decreases as we age. A 2016 study found that the increased levels of CD38 are a primary driver of decreasing levels of NAD+ […]

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Aging & Longevity, Longevity Supplements, NAD+, NMN, NR

NMN Triples NAD+ Levels in Humans

Posted on by David Giacometti

(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of Metrobiotech, whose NMN product MIB-626 was used in this research published Feb 19 2022. MIB-626, an […]

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Aging & Longevity, Longevity Supplements, NAD+, NMN

Why Dr. Sinclair takes NMN instead of NR

Posted on by David Giacometti

There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]

Continue reading →