NMN & NAD+ PRECURSORS

NMN Protects Mitochondria and Reduces Heart Injury in Septic Mice

This study demonstrated that NMN protected heart function in septic mice by reducing mitochondrial free [...]

READ MORE
09
Dec
NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

READ MORE
04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

READ MORE
15
Oct
NMN Improved Aging Parameters in Clinical Trial

[...]

READ MORE
11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

[...]

READ MORE
30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

READ MORE
22
Aug

LATEST ARTICLES

Longevity Supplements, Research

All About Shilajit And Its Medicinal Use

Posted on by Ben Johnson
Lens, Finger, Hand, Camera lens, Cameras & optics,

Shilajit is a tar-like sticky black substance found mainly in mountainous regions. It is primarily found in the Himalayas and is vastly popular in South Asia. Shilajit has a range of benefits associated with it. It is quite famous for its boosting effects on male sexual wellness and fertility. You can see the dark color […]

Continue reading →
Bone & Muscle, Longevity Supplements, Research

Resveratrol Prevents Skeletal Muscle Atrophy and Senescence

Posted on by David

Resveratrol (RSV) is a natural polyphenolic compound with antioxidant, anti-inflammatory, and anti-senescence and antitumor effects.  A new study investigated the effects of resveratrol (RSV) on cigarette smoke (CS)-induced skeletal muscle atrophy and cellular senescence in mice.   Thirty-two male mice were randomly divided into four groups: the control group (N), the resveratrol group (RSV), the emphysema […]

Continue reading →
Aging & Longevity, Longevity Supplements

Fisetin Effectively Eliminates Senescent Cells and Restores Stem Cells

Posted on by David

Fisetin is a flavonoid found in fruits and vegetables and has been shown to have powerful senolytic properties.  In a new study, fisetin was shown to prevent immune cells from becoming senescent, allowing them to enter into a state of apoptosis or cellular suicide, a normal process at the end of a cell’s life cycle. […]

Continue reading →
Longevity Supplements

NMN restores kidney function and prevents kidney damage

Posted on by David

Use of NMN supplements was shown to activate Sirtuin-1, one of the body’s self repair enzymes, to repair kidney damage and restore kidney function in mice. (1) Kidney damage accumulates with age As we age, we accumulate kidney scarring and tissue hardening, which can impede the kidneys ability to filter proteins in the blood and […]

Continue reading →
NAD+

NAD+ IV increases NAD+ levels in blood plasma 400% in humans

Posted on by Ben Johnson

This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Surprisingly, no change in plasma (NAD+) or […]

Continue reading →
Longevity Supplements

Oral Hyaluronic Acid: Advanced Support for Skin, Joint Health and Longevity

Posted on by Ben Johnson

  Supplementation with HLA may improve joint function, reduce wrinkles and even extend lifespan. What is Hyaluronic Acid? Hyaluronic acid (a.k.a. hyaluronan, HA, or HLA) is a substance naturally found in many areas of the human body including the skin, eyes, and synovial fluid of the joints. Preserves Tissue Hydration More than 50% of the […]

Continue reading →
Research

Increasing NMN Transporter in the Brain Reduces Age-Related Muscle Decline

Posted on by David

A new study shows that increased levels in the brain of a molecule called Slc128a, which transports NMN into cells, reduces a type of muscle decline in older adults called sarcopenia. Likewise, they showed that reducing levels of Slc128a in the brain caused the muscles to become fatigued and weakened again. Doubling Slc128a Dramatically Improved […]

Continue reading →
Aging & Longevity, Cardiovascular, Research

Heart Disease Related to Accumulation of DNA Damage and Oxidative Stress

Posted on by David

As we age, the risk for clogged arteries, brittle blood vessels, and heart failure increase. A recent study looking at the DNA in numerous individual heart cells tells the story of why this occurs Buildup of Damaged DNA and Faltering Ability to Repair Damage In a ground-breaking study spanning 0 to 82 year olds, they […]

Continue reading →
Longevity Supplements

Why Dr. Sinclair takes NMN instead of NR

Posted on by Ben Johnson

There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were […]

Continue reading →
Aging & Longevity, NAD+, Research

NAD+ and the Hallmarks of Aging Series – Part 9: Altered Intercellular Communication

Posted on by Ben Johnson

Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell). In order to work collectively and maintain the homeostasis across multiple tissues, our cells have developed multiple different ways to receive, process, and transmit information between each other, including endocrine, […]

Continue reading →
Longevity Supplements, Metabolic Health, Neurological, Research

Newly Found Benefits of Resveratrol in Health and Anti-aging

Posted on by Ben Johnson

Resveratrol is a polyphenol derived from plants with antioxidant properties that have been shown to enhance the activation of the body’s own self-repair proteins, called sirtuins. When sirtuins are activated, the effect is delayed aging, which has been demonstrated in a wide spectrum of experimental models, including mammals.

Continue reading →