NMN & NAD+ PRECURSORS

NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

“We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway [...]

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04
Nov
Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and [...]

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15
Oct
NMN Improved Aging Parameters in Clinical Trial

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11
Oct
NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

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30
Aug
Long Term NMN Use Extends Lifespan and Healthspan in Mice with Sex-Specific Effects

This study examined the effects of long-term NMN supplementation on lifespan, healthspan, and metabolic health [...]

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22
Aug
NMN Enhances Cellular Protection and Cognitive Function in Alzheimer’s Disease Mice

[...]

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20
Aug

LATEST ARTICLES

Cardiovascular, NMN, Research

Study Shows NMN Reduces Arterial Stiffness & Blood Pressure

Posted on by HB

“Several human clinical trials indicate that NR and NAM supplementation decrease the risk factors of CVDs, such as hypertension, arterial stiffness, and elevated level of low-density lipoprotein cholesterol 13,14.”

Although NMN has been proven to improve vascular dysfunction in mice, it has not been thoroughly evaluated in humans.

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Cardiovascular, NMN, Research

New Human Trial Shows NMN Reduced Blood Vessel Stiffness and Significantly Decreased Diastolic Blood Pressure

Posted on by David

A new human trial using 36 healthy middle-aged participants was recently published showing positive efficacy for NMN.  In this 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial, it was shown that just 125mg of NMN twice per day reduced blood vessel stiffness and significantly decreased diastolic blood pressure in participants with elevated glucose levels. (1) NAD+ […]

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Aging & Longevity, Metabolic Health, NAD+, NMN, Research

NMN lowers Cholesterol, bodyweight, and blood pressure in 28 day trial with overweight older adults

Posted on by David Giacometti

A regimen of 1000 mg of MIB-626 twice daily was safe and efficacious

MIB-626 treatment was associated with a substantial increase in blood NAD level from baseline to days 14 and 28

Circulating NMN levels did not change significantly in either group…

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Aging & Longevity, Longevity Supplements, Research

Major Research Studies Show Lifespan Extension from Green Tea

Posted on by HB

Reduction in All-Cause Mortality Correlates with Green Tea Consumption.

Numerous large-scale studies with over 300,000+ participants have demonstrated that green tea consumption is associated with a significant decrease in all-cause mortality.

Studies of this length and magnitude are rare. 

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Aging & Longevity, Longevity Supplements, Research

The Power of Green Tea Extract: Unlocking Health and Longevity Benefits

Posted on by David

Green Tea: A Brief Overview Green tea is a popular beverage that has been consumed for thousands of years, originating in China and spreading throughout the world. It is made from the leaves of Camellia sinensis, a species of plant native to Asia. Unlike black and oolong tea, which are made from fermented leaves, green […]

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Longevity Supplements, Research

The Science Behind Resveratrol: Metabolic Health Breakthroughs

Posted on by David Giacometti

The results showed that Resveratrol intake significantly lowered cholesterol and blood glucose levels (HbA1c, total cholesterol, LDL and HDL).

“These results suggest that Resveratrol (RSV) has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of Resveratrol intake is for obese and diabetic patients.”

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Longevity Supplements, Research

Resveratrol: A Review of Human Clinical Trials

Posted on by David

  Resveratrol, a naturally occurring compound found in grapes, berries, and other plants, has been the subject of numerous studies for its potential health benefits. It is known for its antioxidant, anti-inflammatory, and cardiovascular properties. In recent years, many human clinical trials have been conducted to investigate the effects of resveratrol on human health, including […]

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Lifestyle, Diet & Fitness, NMN, Research

NMN Human Trial Shows Increased Endurance, NAD+ Blood Levels, and Benefits to Bioage

Posted on by David

A new NMN human trial using 80 middle-aged healthy adults showed that NMN supplementation was both safe and well tolerated.  It also showed that NMN significantly raised NAD+ blood levels, increased endurance, and benefited bioage. Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels are known to decline […]

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Intestinal Health, NR, Research

NAD Precursors Cycle Between Host Tissues and the Gut Microbiome

Posted on by David Giacometti

Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis.

Thus, gut microbiota provide an alternative route from NAM to NAD, bypassing the salvage synthesis pathway, in intestine and liver

Orally delivered NR was found in the GI tract but not in other peripheral tissues, indicating rapid metabolism of NR before it enters the circulation (Figure S4A). Only a small fraction of NAD in the liver and small intestine was M+9, indicating minimal direct assimilation of NR

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